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Emergency Psychiatric clinical trials

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NCT ID: NCT06430489 Not yet recruiting - Suicidal Ideation Clinical Trials

Treatment of Suicidal Ideation in the Emergency Department Using Nitrous Oxide

PROTORISC
Start date: June 2024
Phase: Phase 2
Study type: Interventional

Suicide prevention is a major public health concern, with nearly 9,000 suicides and over 200,000 suicide attempts reported each year in France. Suicide attempts and suicidal ideation are among the most frequent reasons for emergency room visits and psychiatric hospitalizations. Although there is no approved pharmacological treatment for suicidal crises, some psychiatric treatments appear promising. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has shown promising results in reducing suicidal ideation. However, its use is limited due to its side effects. Nitrous oxide, another NMDA receptor inhibitor commonly used in anesthesia and pain management, has demonstrated rapid antidepressant effects and few side effects. Given its rapid and lasting effects, nitrous oxide could swiftly alleviate suicidal ideation.

NCT ID: NCT06406972 Recruiting - Suicide Clinical Trials

Brief Admission by Self-referral for Individuals With Self-harm: Effects on Compulsory Care

Start date: September 15, 2010
Phase:
Study type: Observational [Patient Registry]

Brief Admission by self-referral (BA) is a standardized treatment model, providing patient-controlled and person-centered care. It was developed to reduce self-harm and compulsory care by promoting autonomy. Randomized clinical trials have not yielded significant between group differences with respect to inpatient care, including compulsory care. The major difficulty in evaluating BA is preventing the control group from cross-contamination, as in the implementation process of BA, all physicians, all inpatient and outpatient staff as well as managers need to be informed and undergo basic education regarding the intervention. As BA addresses a prevalent and frustrating issue in psychiatric health care, there is considerable risk that the approach leaks to the control group, reducing the possibility to detect between-group differences. In the current study this will be addressed through a register-based approach, comparing similar clinics, implementing BA at different timepoints over time. Individuals with traits of borderline personality disorder will be included and comparisons will be made with respect to compulsory care, voluntary inpatient care and mortality.

NCT ID: NCT06357195 Not yet recruiting - Aging Clinical Trials

DIAMOND-Lewy Guidelines for Antipsychotic Use in Older Patients

Start date: May 30, 2024
Phase:
Study type: Observational

The goal of this observational study is to learn about current practices for the acute neuropsychiatric management of older adults during emergency department (ED) visits. Researchers will compare current standard of care practices with implemented guideline practice to see if standardized medication guidelines help reduce the usage of antipsychotics and/or benzodiazepines during acute presentations. The main questions this study aims to answer are: - How many older adults are receiving antipsychotics or benzodiazepines during emergency department visits? - Why are older adults receiving antipsychotics or benzodiazepines during emergency department visits? - How many older adults who receive antipsychotics or benzodiazepines during emergency department visits have an underlying cognitive or movement disorder? - What effects does administration of antipsychotics or benzodiazepines during emergency department visits have on patient outcomes in older adults and adults with neurocognitive disorders? - Does implementation of standardized medication guidelines help reduce the usage of antipsychotics and/or benzodiazepines during acute presentations?

NCT ID: NCT06233747 Recruiting - Suicidal Ideation Clinical Trials

Improving Care, Accelerating Recovery and Education

I-CARE
Start date: February 29, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to test the I-CARE program in children who are in a medical hospital awaiting inpatient mental health treatment. The main questions it aims to answer are: - Can the I-CARE program be used at the medical hospitals and do the patients and hospital staff like the program? - Does the I-CARE program lower patients' emotional distress, thoughts about suicide or suicide attempts? Patients will complete as many of the 7 I-CARE videos as possible during their stay at the medical hospital and fill out online surveys. There are workbook activities that go with each I-CARE video. A hospital staff member will help the patient do the videos and workbook activities.

NCT ID: NCT04902391 Recruiting - Mental Health Clinical Trials

A Patient-Partnered, Pan-Canadian, Comparative Effectiveness Evaluation of an Acute Pediatric Mental Health and Addiction Care Bundle

Start date: February 9, 2022
Phase: N/A
Study type: Interventional

The investigators will determine, in an 8-site, hybrid Type 1 cluster randomized effectiveness implementation trial, if an acute mental health care bundle, compared to standard care, improves wellbeing at 30 days in children and youth seeking emergency department care for mental health and substance use concerns.

NCT ID: NCT04292379 Completed - Mental Health Clinical Trials

An Innovative Model of Pediatric Acute Mental Health and Addictions Care

Start date: January 29, 2020
Phase:
Study type: Observational

The investigators will implement and evaluate an integrated, evidence-based bundle of family-centred, pediatric emergency mental health and addictions care.

NCT ID: NCT03216941 Completed - Clinical trials for Psychiatric Disorder

Randomised Trial Ketiapine Olanzapine Fast Sedation Agitated Patients Emergency Ward

IM-OK-FAST
Start date: January 1, 2015
Phase: Phase 4
Study type: Interventional

comparison of intramuscular olanzapine and ketamine efficacy as first medication for fast sedation of patients with agitation and aggressive behavior. Five hundred patients with agitation caused by psychiatric disorder were randomly assigned under double-blind conditions to receive olanzapine or ketiapine. The Overt Agitation Severity Scale, Overt Aggression Scale and Ramsay Sedation Scale will be applied within 12 hours after the first dosage.