Emergencies Clinical Trial
— CHESTOMYOfficial title:
Evaluation of Regional Ventilation Distribution in Patients Affected by Abdominal Sepsis After Emergent Laparotomy
The goal of this clinical trial is to evaluate regional ventilation distribution in patients admitted to the intensive care unit after emergent laparotomy due to abdominal sepsis. The main question it aims to answer is: • evaluate if patients admitted after an open abdomen strategy have a different regional ventilation distribution compared to patients in which abdomen is closed at the end of the procedure Participants will undergo non-invasive monitoring (esophageal pressure and electrical impedance tomography) and an blood gas analysis samples. Researchers will compare open abdomen group and closed abdomen group to see if the ventilation distribution pattern is different.
Status | Not yet recruiting |
Enrollment | 30 |
Est. completion date | December 31, 2024 |
Est. primary completion date | May 30, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 90 Years |
Eligibility | Inclusion Criteria: - Age > 18 and < 90 years - Admitted to the ICU after emergent laparotomy for abdominal sepsis - Acute respiratory failure Exclusion Criteria: - Controindications to electrical impedance tomography monitoring - body mass index > 40 kg/m2 - Haemodinamic instability - Pneumothorax - Pneumomediastinum - refusal to participate |
Country | Name | City | State |
---|---|---|---|
Italy | Azienda Ospedaliero Universitaria Sant'Anna | Ferrara |
Lead Sponsor | Collaborator |
---|---|
Università degli Studi di Ferrara | University of Milan |
Italy,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Chest-wall compliance (Ccw) measured using respiratory parameters from the Ventilator | Different chest wall compliance between the two groups measured using the esophageal catheter. Chest wall compliance will be calculated using the data provided from the respiratory monitoring (i.e. esophageal balloon catheter). | Day 0 | |
Primary | Chest-wall compliance (Ccw) measured using respiratory parameters from the Ventilator | Different chest wall compliance between the two groups measured using the esophageal catheter. Chest wall compliance will be calculated using the data provided from the respiratory monitoring (i.e. esophageal balloon catheter). | Day 1 | |
Primary | Chest-wall compliance (Ccw) measured using respiratory parameters from the Ventilator | Different chest wall compliance between the two groups measured using the esophageal catheter. Chest wall compliance will be calculated using the data provided from the respiratory monitoring (i.e. esophageal balloon catheter). | Day 2 | |
Secondary | Regional ventilation distribution measured using Electrical impedance tomography | The researchers will evaluate differences in ventilation distribution pattern among the different weaning trials using Electrical Impedance Tomography and focusing on:
Regional ventilation distribution Regional inhomogeneity Regional compliance distribution Center of Ventilation Regional ventilation delay Regional compliance |
Day 0 | |
Secondary | Regional ventilation distribution measured using Electrical impedance tomography | The researchers will evaluate differences in ventilation distribution pattern among the different weaning trials using Electrical Impedance Tomography and focusing on:
Regional ventilation distribution Regional inhomogeneity Regional compliance distribution Center of Ventilation Regional ventilation delay Regional compliance |
Day 1 | |
Secondary | Regional ventilation distribution measured using Electrical impedance tomography | The researchers will evaluate differences in ventilation distribution pattern among the different weaning trials using Electrical Impedance Tomography and focusing on:
Regional ventilation distribution Regional inhomogeneity Regional compliance distribution Center of Ventilation Regional ventilation delay Regional compliance |
Day 2 | |
Secondary | Mortality in the intensive care unit | Mortality rate in ICU | Up to 28 days | |
Secondary | Infection rate during ICU stay | New diagnosis of infections during the ICU stay | Up to 28 days |
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