Clinical Trials Logo
  1. Home
  2. Embryo Implantation
  3. NCT05555121

Rescue Progesterone Supplementation During Frozen Embryo Transfer — P4R  

Fertility Issues Clinical Trial

Official title:
Rescue Progesterone Supplementation in Patients With Low Progesterone on the Day of Embryo Transfer for Artificial Endometrial Preparation Cycles: a Non-inferiority Study

Clinical Trial Summary

Endometrin is a progesterone supplement prescribed during in vitro fertilization (IVF) for preparation for embryo transfer. The usual dose of Endometrin is 100 mg two to three times per day in the form of an effervescent tablet to be inserted vaginally. The purpose of this research project is to evaluate the dose response of the Endometrin when determined based on the blood level of progesterone on the day of the FET. According to the literature, a predefined level of progesterone in the blood should be reached in order to have favorable conditions for pregnancy. The hypothesis being that a woman with low progesterone levels would benefit from a dose of Endometrin of 600 mg (200 mg 3x/day) to decrease the risk of miscarriage and improve the chances of pregnancy. Women with adequate progesterone levels according to the literature, would continue with the standard dose of progesterone prescribed at clinique ovo which is 300 mg (100 mg 3x/day). PIBF (Progesterone Induced Blocking Factor) levels, a protein found in the blood that could also predict pregnancy outcomes in women using IVF will also be looked at.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05555121
Study type Interventional
Source Clinique Ovo
Contact
Status Active, not recruiting
Phase Phase 2
Start date December 1, 2022
Completion date June 30, 2026
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT04519593 - ABSOLUTELY: A Temporary Uterine Blood Supply Occlusion for Laparoscopic Myomectomy in Patients With UTErine LeiomYoma N/A
Recruiting NCT05980091 - Optimal Timing of Euploid Day 6 Blastocyst Transfer in Frozen HRT Cycles, Day 6 or Day 7 of Progesterone Administration. Phase 1
Recruiting NCT06043609 - Outcome Evaluation After Fertility Preservation
Not yet recruiting NCT05048771 - Fertility and Temporality in Pediatric Oncology
Completed NCT05368194 - Food Intake and Epigenetic Alteration in the Spermatozoa of Singletons and Twins N/A
Recruiting NCT05176535 - Determination of Vaginal Colonization and the Effect of an Oral Probiotic (PROSALVAG) N/A
Recruiting NCT06360471 - Fertility Preservation and Pregnancy and Offspring Health Outcomes in Female Cancer
Recruiting NCT05271981 - Fertility After Uterine Artery Embolization
Recruiting NCT05815719 - Continuous Double Ovarian Stimulation. Phase 4
Recruiting NCT06127875 - Effects of Trying to Conceive Using an Home- or Hospital-based Ovulation Monitoring on Stress
Recruiting NCT05658848 - Effect of Collaborative Infertility Counseling on Coping Strategies and Marital Satisfaction N/A
Not yet recruiting NCT05385848 - Autologous Platelet-rich Plasma (PRP) Infusion to Improve Outcomes in Women With Ovarian Insufficiency: a Pilot Study N/A
Completed NCT04396210 - Patients Perspectives on Discontinuation of Their Fertility Treatment Due to the COVID-19 Pandemic
Completed NCT05134090 - Percutaneous Laparoscopy for Ovarian Tissue Cryopreservation.
Completed NCT05905289 - Survival and Reproductive Outcomes of Malignant Ovarian Germ Cell Tumors
Recruiting NCT05316467 - Weight Management Plus Megestrol Acetate in Early-stage Endometrioid Carcinoma Phase 2/Phase 3
Completed NCT04600869 - Effects of Naturalistic Decision-Making Model-based Oncofertility Care Education N/A
Withdrawn NCT04683237 - Liraglutide Plus Megestrol Acetate in Endometrial Atypical Hyperplasia Phase 2/Phase 3
Not yet recruiting NCT06179420 - The Effectiveness of Advanced Decision Support Tool (OPT-IVF) for IVF Treatment
Recruiting NCT06163079 - Assisted Reproductive Techniques (ART) With Sperm Donation : an Inclusive Model of ART for All Women