Other Clinical Trial - Plasma Biomarkers in Cardiac Valve Surgery

Clinical Trial Summary

The level of four biomarkers will be measured in the patients' plasma after induction of anaesthesia. There biomarkers are NT-ProBNP, ST2, Galectin-3 and GDF-15. The level of these marker will then be correlated with early (30 days) and late (one year) patients' prognosis and with functional recovery (MLHFQ score).

Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.

Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

NCT number	NCT02641665
Study type	Observational
Source	University Hospital of Liege
Contact	Gregory A Hans, MD, PhD
Phone	+3243667655
Email	G.Hans@chu.ulg.ac.be
Status	Recruiting
Phase	N/A
Start date	January 2016
Completion date	December 2018

Plasma Biomarkers in Cardiac Valve Surgery

Clinical Trial Summary

Clinical Trial Description

Study Design

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