Ectopic Pregnancy Clinical Trial
Official title:
The Aromatase Inhibitor and Gnrh Antagonist Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy
The aim of this study is to :
1. Use of the aromatase inhibitor( letrozole) for the treatment of ectopic pregnancy
compared to methotrexate.
2. Use of the Gnrh antagonist for the treatment of ectopic pregnancy compared to
methotrexate.
| Status | Not yet recruiting |
| Enrollment | 120 |
| Est. completion date | September 1, 2022 |
| Est. primary completion date | March 1, 2022 |
| Accepts healthy volunteers | No |
| Gender | Female |
| Age group | 18 Years to 40 Years |
| Eligibility |
Inclusion Criteria: - Patients who have undisturbed ectopic pregnancy .Who are: 1. have no significant pain 2. have an unruptured tubal ectopic pregnancy with an adnexal mass smaller than 35mm with no visible heartbeat 3. have a serum human chorionic gonadotropins level less than 1,500 IU/litre 4. do not have an intrauterine pregnancy (as confirmed on an ultrasound scan) . Exclusion Criteria: 1. An undisturbed ectopic pregnancy and significant pain 2. An undisturbed ectopic pregnancy with an adnexal mass of 35 mm or larger 3. An undisturbed ectopic pregnancy with a fetal heartbeat visible on an ultrasound scan 4. An undisturbed ectopic pregnancy and a serum human chorionic gonadotropins level of 5,000 IU/litre or more 5. intrauterine pregnancy |
| Country | Name | City | State |
|---|---|---|---|
| n/a | |||
| Lead Sponsor | Collaborator |
|---|---|
| Assiut University |
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | determine efficacy of the aromatase inhibitor and Gnrh antagonist to achievement of resolution of ectopic pregnancy determined by serum hCG levels below laboratory immunoassay detection <15 IU/l.Results will be statistically analyzed,then evaluated . | 3 months |
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02995356 -
Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy
|
||
| Completed |
NCT01876004 -
Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy
|
Phase 4 | |
| Not yet recruiting |
NCT05039853 -
Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task
|
N/A | |
| Completed |
NCT00194207 -
Risk Factors of Ectopic Pregnancy
|
N/A | |
| Completed |
NCT00827970 -
Randomized Population-Based Study on Chlamydia Trachomatis Screening
|
N/A | |
| Recruiting |
NCT05374720 -
Analysis of the Molecular Composition of Tubal Cilia in Patients With or Without Ectopic Pregnancy
|
N/A | |
| Completed |
NCT03894735 -
Vitamin D in Ectopic Pregnancies
|
||
| Recruiting |
NCT01860690 -
BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success
|
Phase 4 | |
| Recruiting |
NCT04176549 -
Assessment of Biomarkers in Ectopic Pregnancy
|
||
| Not yet recruiting |
NCT05890066 -
Single-port Versus Multi-port Laparoscopic Surgery for Ectopic Pregnancy
|
N/A | |
| Completed |
NCT01855568 -
Methotrexate Treatment for Ectopic Pregnancy
|
Phase 3 | |
| Recruiting |
NCT06354439 -
Use of Letrozole for Ectopic Pregnancy
|
Phase 4 | |
| Not yet recruiting |
NCT06300333 -
Treatment of Ectopic Pregnancy by Low Dose of Methotrexate
|
||
| Completed |
NCT00194272 -
Two-Dose Methotrexate for Ectopic Pregnancy
|
Phase 3 | |
| Enrolling by invitation |
NCT03579550 -
Hysteroscopic Metroplasty in Unexplained Infertile Women With Dysmorphic Uterus
|
N/A | |
| Completed |
NCT05446012 -
Relationship Between Ectopic Pregnancy and Thyroid Disorders
|
||
| Completed |
NCT00194168 -
Ectopic Pregnancy Biomarkers
|
N/A | |
| Completed |
NCT02152696 -
Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location
|
Phase 3 | |
| Not yet recruiting |
NCT04975984 -
Expectant Management of Ectopic Pregnancy
|
||
| Completed |
NCT04371991 -
Kisspeptin Levels in Early Pregnancy
|