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Use of Letrozole for Ectopic Pregnancy — EcZOL  

Ectopic Pregnancy Clinical Trial

Official title:
Use of Letrozole in the Treatment of Early Ectopic Pregnancy

Clinical Trial Summary

A randomized clinical trial using oral letrozole 10mg/day for 7 days, for treating early cases of ectopic pregnancy, compared to intramuscular methotrexate

Clinical Trial Description

This is a multicenter randomized clinical trial on the use of letrozole in the medical treatment of tubal ectopic pregnancy. Tubal ectopic pregnancy is an abnormal pregnancy in the fallopian tube. They occurred in about 8% of all pregnancies presenting to the emergency department. Methotrexate (MTX), administered systemically (intramuscularly), is a widely used medication for the treatment of unruptured tubal ectopic pregnancies and has been recommended as first-line treatment for early cases of ectopic pregnancy. Letrozole is an aromatase inhibitor and can suppress estradiol levels. Some recent studies have shown that its use can be applied in cases of ectopic pregnancy. The aim of this non-inferiority clinical trial is to verify that letrozole treatment is non-inferior to methotrexate treatment in women with early ectopic pregnancy who are hemodynamically stable. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06354439
Study type Interventional
Source Hospital de Clinicas de Porto Alegre
Contact Ricardo F Savaris, MD, PhD
Phone +55 51 997781966
Email rsavaris@hcpa.edu.br
Status Recruiting
Phase Phase 4
Start date March 27, 2024
Completion date December 31, 2026
View Details
See also
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