Clinical Trials Logo
  1. Home
  2. Ectopic Pregnancy
  3. NCT02152696

Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location — ACTorNOT  

Ectopic Pregnancy Clinical Trial

Official title:
Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location - a Randomized Clinical Trial of Women at Risk for an Ectopic Pregnancy: Active Treatment Versus No Treatment

Clinical Trial Summary

This is a randomized controlled trial to compare three currently available management strategies for women with a persisting pregnancy of unknown location (PPUL), which makes them at-risk for ectopic pregnancy. We will recruit hemodynamically stable women with a confirmed PPUL to be randomized to one of three strategies: 1) Uterine evacuation followed by methotrexate (MTX) for some (those that have evidence of a non visualized ectopic pregnancy) 2) Empiric treatment with MTX for all 3) Expectant management. Randomization will be 1:1:1 into these three arms. After randomization, they will be followed and treated clinically as is indicated by the progression of their condition. Primary outcome measures: uneventful decline of hCG to 5 IU/mL.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02152696
Study type Interventional
Source Yale University
Contact
Status Completed
Phase Phase 3
Start date July 25, 2014
Completion date August 19, 2019
View Details
See also
  Status Clinical Trial Phase
Completed NCT02995356 - Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy
Completed NCT01876004 - Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy Phase 4
Not yet recruiting NCT05039853 - Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task N/A
Completed NCT00194207 - Risk Factors of Ectopic Pregnancy N/A
Completed NCT00827970 - Randomized Population-Based Study on Chlamydia Trachomatis Screening N/A
Recruiting NCT05374720 - Analysis of the Molecular Composition of Tubal Cilia in Patients With or Without Ectopic Pregnancy N/A
Completed NCT03894735 - Vitamin D in Ectopic Pregnancies
Recruiting NCT01860690 - BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success Phase 4
Recruiting NCT04176549 - Assessment of Biomarkers in Ectopic Pregnancy
Not yet recruiting NCT05890066 - Single-port Versus Multi-port Laparoscopic Surgery for Ectopic Pregnancy N/A
Completed NCT01855568 - Methotrexate Treatment for Ectopic Pregnancy Phase 3
Not yet recruiting NCT04308343 - The Aromatase Inhibitor and Gnrh Antagonist Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy N/A
Recruiting NCT06354439 - Use of Letrozole for Ectopic Pregnancy Phase 4
Not yet recruiting NCT06300333 - Treatment of Ectopic Pregnancy by Low Dose of Methotrexate
Completed NCT00194272 - Two-Dose Methotrexate for Ectopic Pregnancy Phase 3
Enrolling by invitation NCT03579550 - Hysteroscopic Metroplasty in Unexplained Infertile Women With Dysmorphic Uterus N/A
Completed NCT05446012 - Relationship Between Ectopic Pregnancy and Thyroid Disorders
Completed NCT00194168 - Ectopic Pregnancy Biomarkers N/A
Not yet recruiting NCT04975984 - Expectant Management of Ectopic Pregnancy
Completed NCT04371991 - Kisspeptin Levels in Early Pregnancy