Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Artery Surgery

Echocardiography, Transesophageal Clinical Trial

Official title: Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Cross-Clamping During Carotid Endarterectomy Under General Anesthesia

Status Recruiting

Clinical Trial Summary

This will be a prospective, randomized, double-blinded, cross-over clinical trial to compare the effects of phenylephrine or norepinephrine on cardiac function during carotid artery surgery in patients under general anesthesia. The effect of the vasopressor on cardiac function will be measured using electrocardiography, transesophageal echocardiography and cardiac troponin I intraoperatively and postoperatively. We will use a cross-over pattern since both drugs exhibit rapid onset and short duration of action. We hypothesize that there will be less myocardial ischemia associated with the use of norepinephrine when compared with phenylephrine during carotid artery surgery.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double-Blind

Related Conditions & MeSH terms

• Echocardiography, Transesophageal
• Endarterectomy, Carotid
• Vasopressor Agents

• NCT number: NCT00294606
• Study type: Interventional
• Source: Lawson Health Research Institute
• Contact: Rosemary A Craen, MD, FRCPC
• Phone: (519) 663-3022
• Email: rosemary.craen@lhsc.on.ca
• Status: Recruiting
• Phase: N/A
• Start date: February 2006
• Completion date: February 2006