Eating Behavior Clinical Trial
Official title:
Effect of Consumption on Cognitive Processes
Verified date | March 2018 |
Source | University of Birmingham |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
To get a better understanding of the interaction between metabolism, neural responses, cognitive processes and appetite the investigaters will examine the effect of food consumption on cognitive processes. The investigaters will look at the effect of satiation on cognitive performance on both a behavioural and neuronal level. In this study participants will undergo functional magnetic resonance imaging (fMRI) measurements while performing a food reward and inhibition task, and in addition perform a memory, working memory and delay discount task, once when hungry and once when full.
Status | Completed |
Enrollment | 31 |
Est. completion date | April 10, 2018 |
Est. primary completion date | April 10, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 45 Years |
Eligibility |
Inclusion Criteria: - Healthy subjects - Age 18-45 years at start of the study - Right-handedness (including left-handers could bias the results because of the laterality of brain functions) - Ability to give informed consent - Fluent English speaking - Willingness to be informed about chance findings of pathology Exclusion Criteria: - Subjects who have a non-removable metal object in or at their body, such as, for example: Heart pace-maker, artificial heart valve, metal prosthesis, implants or splinters, non-removable dental braces - Tattoos, that are older than 15 years - Claustrophobia - Pathological hearing ability or an increased sensitivity to loud noises - Lack of ability to give informed consent - Operation less than three months ago - Acute illness or infection during the last 4 weeks - Cardiovascular disorders (e.g., hypertrophic cardiomyopathy, long QT syndrome) - Moderate or severe head injury - Eating disorders - No metabolic (e.g. metabolic disorder, diabetes, insulin resistance), psychological (e.g. depression) or neurological (e.g. epilepsy, headache disorder, multiple sclerosis, traumatic brain injuries) diseases or medication in relation to these diseases. - Current weight loss regimens, or more then 5kg weight loss in the last 3 months - Smoking - Current pregnancy or breastfeeding - Current or past history of drug or alcohol dependency - alcohol consumption exceeding 12 units a week - Food allergies (e.g. peanut allergy lactose and gluten intolerance) or vegetarian/vegan diet - Disliking the study lunch |
Country | Name | City | State |
---|---|---|---|
United Kingdom | University of Birmingham School of Psychology | Birmingham | Midlands |
Lead Sponsor | Collaborator |
---|---|
University of Birmingham |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | fMRI brain responses during inhibition | - Neural activation correct No-Go vs. Go trail. Subjects neural activation when they are instructed to go (press) when seeing toiletry or stationary items and react correctly compared to when subjects are instructed not to go (no press) when seeing a food or sport and withhold correctly | 14 minutes | |
Primary | fMRI brain repsonse during inhibition to a food stimuli | Neural activation during correct inhibition food vs. non-food stimuli trail. Comparing the brain response when subjects correctly withhold for food vs a sports item. | 14 minutes | |
Primary | fMRI neural network during inhibition to a food stimuli | Functional connectivity during correct inhibition food vs. non-food stimuli trail. | 14 minutes | |
Secondary | Word recall | Recall accuracy. The researchers will count the correct amount of words remembered in this task and calculate % of words remembered in total, and differentiate between the three categories (food/neutral/emotional) | 10 minutes | |
Secondary | Delay discount of food reward | - Area under the curve for delay of choosing a food item. Subjects have to choice between a certain amount of food now, or more (which varies between 1-20 pieces) food later (which will vary from 1 day, 1 months and 1 year). | 10 minutes | |
Secondary | Delay discount of money reward | - Area under the curve for delay of choosing a amount of money. Subjects have to choice between a certain amount of money now, or more (which varies between 1-100 pound) money later (which will vary from 1 day, 1 months and 1 year). | 10 minutes | |
Secondary | Reaction time to target | Particpants have to hold a food or non-food image in working memory for later retrieval. Subsequently, particpants have to respond to a target and ignore a distracter, both paired with an image. As a outcome there are three reaction time critical conditions (i) valid trials, when the memorized item appeared next to the search target; (ii) invalid trials, when the memorized item appeared next to a distracter in the search display; (iii) neutral trials in which the memorized item did not re-appear in the search display. The | 25 minutes | |
Secondary | fMRI brain activity in food picture task | - Brain responses for food stimuli compared to non-food stimuli. We will measure this by showing subjects food and non-food images while preforming and fMRI-scan and subtract activity during non-food images from the activity pattern when looking at food images. | 18 minutes |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03117374 -
Impact of Web-based School Nutrition Intervention to Increase Fruits, Vegetables and Dairy
|
N/A | |
Completed |
NCT04025099 -
Internal Cues Versus External Cues for Eating and Activity
|
N/A | |
Recruiting |
NCT06111040 -
Nurturing Needs Study: Parenting Food Motivated Children
|
N/A | |
Completed |
NCT05485168 -
Combined Effects of Sequential Variety and Portion Size on Meal Intake of Women
|
N/A | |
Completed |
NCT03241121 -
Study of Eating Patterns With a Smartphone App and the Effects of Time Restricted Feeding in the Metabolic Syndrome
|
N/A | |
Completed |
NCT03850990 -
Effect of Gut-Cued Eating on BMI and Efficacy of Open-Label Placebo to Augment Weight Loss
|
N/A | |
Completed |
NCT02470949 -
Influence of a Monopoly Game on Subtle Behaviors
|
N/A | |
Recruiting |
NCT01863212 -
The Role of the FTO Gene in Reward System Activation in Obese and Healthy Subjects
|
N/A | |
Completed |
NCT02729675 -
Innovative Approaches to Increase F&V Intake Thru Worksites
|
Phase 2 | |
Completed |
NCT05405244 -
Examination of Bromocriptine on Homeostatic and Hedonic Mechanisms of Food Intake in Individuals at High Risk for T2DM
|
Phase 3 | |
Completed |
NCT04971811 -
Effects of Energy Density on Self-served Snacks in Preschool Children
|
N/A | |
Completed |
NCT05019872 -
Al Dente or Well Done? The Eating Rate of a Pasta Meal Modified by Texture
|
N/A | |
Completed |
NCT04605224 -
Effectiveness of a Culinary Class on Food Literacy and Eating Behaviours of Francophone High School Students
|
||
Not yet recruiting |
NCT06448117 -
Mind Nutrition Study: Nutrition in the Prevention of Depressiveness and Sustaining Work Ability
|
N/A | |
Recruiting |
NCT04526743 -
Eating Behavior and Weight Trajectory After Bariatric Surgery
|
||
Active, not recruiting |
NCT05026411 -
Food Reward Circuit Change by Orthodontics
|
N/A | |
Completed |
NCT05173311 -
Pilot Study: The Effectiveness of a Mobile Application in Increasing Vegetable Acceptance
|
N/A | |
Completed |
NCT05149066 -
#KindGirlsInACTion: A Programme for the Promotion of Mental Health of Female Adolescents
|
N/A | |
Completed |
NCT03779321 -
Effect of Food Acceptability on Appetite Hormones' Response in Normal Weight vs. Obese Male Subjects
|
N/A | |
Recruiting |
NCT06108128 -
Food for Thought: Executive Functioning Around Eating Among Children
|
N/A |