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Effect of Intranasal Oxytocin on Appetite and Caloric Intake in Men and Women

Eating Behavior Clinical Trial

Official title:
Effect of Intranasal Oxytocin on Appetite and Caloric Intake in Humans

Clinical Trial Summary

Exciting advances have led to the concept that hormones can modulate appetite and food intake. Oxytocin is a peptide hormone that is released in regions throughout the brain, including areas involved in food motivation. Animal studies suggest that oxytocin may reduce food intake. The effects of oxytocin administration on eating behavior in humans, which could have important implications in eating-related disorders ranging from obesity to anorexia nervosa, have not been investigated. This double-blind placebo-controlled cross-over study of single-dose oxytocin administration investigates whether:

1. Caloric intake will decrease following administration of oxytocin versus placebo

2. Appetite will decrease following administration of oxytocin versus placebo

3. Resting energy expenditure will increase following administration of oxytocin versus placebo

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01513499
Study type Interventional
Source Massachusetts General Hospital
Contact
Status Completed
Phase Early Phase 1
Start date January 2012
Completion date January 2014
View Details
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