Dual-task Performance in Young-onset PD

Early Onset Parkinson Disease Clinical Trial

Official title:

Decrement of the Dual-task Performance in Individuals With Young-onset Parkinson's Disease and the Training Effects

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04033393
• Other study ID #: 2019-05-005C
• Status: Not yet recruiting
• Phase: N/A
• Start date: August 1, 2019
• Est. completion date: July 31, 2022

Study information

• Verified date: July 2019
• Source: National Yang Ming University
• Contact: Yang Yearu, Ph.D.
• Phone: +88628267279
• Email: yryang[@]ym.edu.tw
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study aimed to investigate the effects of Game based dual-task training with treadmill on executive function and dual-task performance in individuals with early-onset PD and discuss the correlation between the change values of executive function and dual-task performance after training. Besides, investigate cortical activation after training.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 40
• Est. completion date: July 31, 2022
• Est. primary completion date: July 31, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• Diagnosed as PD and Hoehn and Yahr stage between 1~3

• Age between 20 to 80

• Able to walk 10 m independently without an assistive device

• A score of greater than or equal to 24 on the mini-mental state examination (MMSE)

• In stable medical condition allowing participation in the testing protocol and intervention

Exclusion Criteria:

• Any comorbidity or disability other than PD that would preclude gait training

• Any uncontrolled health condition for which exercise was contraindicated

• Any neurological or orthopedic disease that might interfere with the study

• Server freezing of gait, FOG questionnaire > 15

Related Conditions & MeSH terms

• Early Onset Parkinson Disease
• Early Stage Parkinson Disease
• Parkinson Disease

Intervention

Other:
• Game based dual-task training
Participants in the experimental group will receive game based dual-task training with a treadmill
• Treadmill training
Participants in the control group will receive treadmill training

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
National Yang Ming University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Dual-task walking performance	To evaluate gait parameters while doing dual-task walking	Change from baseline at 8 weeks
Secondary	Single walking performance	To evaluate gait parameters while doing single walking	Change from baseline at 8 weeks
Secondary	Timed up and go test	To evaluate functional walking ability	Change from baseline at 8 weeks
Secondary	Parkinson's Disease Questionnaire 39	To evaluate the quality of life	Change from baseline at 8 weeks
Secondary	Frontal lobe battery test-Chinese version	To evaluate executive function	Change from baseline at 8 weeks
Secondary	Trail-making test	To evaluate executive function	Change from baseline at 8 weeks
Secondary	Stroop color and word test-Chinese version	To evaluate executive function	Change from baseline at 8 weeks
Secondary	Verbal fluency test-Chinese version	To evaluate executive function	Change from baseline at 8 weeks
Secondary	Digit span test	To evaluate executive function	Change from baseline at 8 weeks
Secondary	Dual-task costs	To compare the cost between doing dual task and single task	Change from baseline at 8 weeks
Secondary	Functional near-infrared spectroscopy	To evaluate the changes of blood perfusion in frontal lobe	Change from baseline at 8 weeks