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Clinical Trial Summary

This is a Phase III, global, randomized, open-label, multicenter, study evaluating the efficacy and safety of adjuvant giredestrant compared with endocrine therapy of physician's choice in participants with medium- and high-risk Stage I-III histologically confirmed estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative early breast cancer. In addition, an open-label exploratory substudy will explore the safety and efficacy of giredestrant in combination with abemaciclib in a subset of the primary study population.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04961996
Study type Interventional
Source Hoffmann-La Roche
Contact Reference Study ID Number: GO42784 https://forpatients.roche.com
Phone 888-662-6728 (U.S. Only)
Email global-roche-genentech-trials@gene.com
Status Recruiting
Phase Phase 3
Start date August 27, 2021
Completion date November 21, 2033

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