Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders.

Parkinson Disease Clinical Trial

Official title: Changes of the Neuronal Activity in the Subthalamic Nucleus Under Propofol Sedation During Stereotactic Electrode Implantation.

Status Enrolling by invitation

Clinical Trial Summary

The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.

Clinical Trial Description

Deep Brain Stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients. The procedure is uncomfortable to the patients who have to remain motionless during the whole surgery. Previous reports of electrode positioning under general anesthesia was found to be less accurate. This result was probably due to the effect of the anesthetics on the electrical activity of the Basal Ganglia.

The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to propofol sedation. Electrical activity of single neurons will be recorded before and after sedation. ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Disease
• Dystonia
• Movement Disorders
• Parkinson Disease
• Parkinsonian Disorders
• Tourette Syndrome

• NCT number: NCT00355927
• Study type: Interventional
• Source: Hadassah Medical Organization
• Status: Enrolling by invitation
• Phase: N/A
• Start date: September 2006
• Completion date: July 2008