Neural Mechanisms of Successful Intervention in Children With Dyslexia

Dyslexia, Developmental Clinical Trial

Official title:

Neural Mechanisms of Successful Intervention in Children With Dyslexia

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT04323488
• Other study ID #: 52231
• Status: Enrolling by invitation
• Phase: N/A
• Start date: May 1, 2021
• Est. completion date: June 30, 2024

Study information

• Verified date: August 2021
• Source: Stanford University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Dyslexia, an impairment in accurate or fluent word recognition, is the most common learning disability affecting roughly ten percent of children. This proposal capitalizes on cutting edge neuroimaging methods, in combination with reading education programs, to generate a new understanding of how successful reading education shapes the development of the brain circuits that support skilled reading. A deeper understanding of the mechanisms of successful remediation of dyslexia, and individual differences in learning, will pave the way for personalized approaches to dyslexia treatment.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 40
• Est. completion date: June 30, 2024
• Est. primary completion date: June 30, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 8 Years to 12 Years

Eligibility

Inclusion Criteria:

• Reading difficulties defined as low scores on standardized measures of reading skills

Exclusion Criteria:

• no major contraindication for MRI (braces, metal implants, pacemakers, vascular stents, or metallic ear tubes).

• Because the study involves measurements of reading and language ability, new recruits will be native English speakers.

• Subjects have no history of neurological disorder, significant psychiatric problems

• exclude claustrophobic subjects since an MRI might be uncomfortable for them.

Related Conditions & MeSH terms

• Dyslexia
• Dyslexia, Developmental

Intervention

Behavioral:
• Lindamood-Bell Seeing Stars
Seeing Stars in a curriculum developed by Lindamood-Bell. It is published and openly available. It involves systematic training in the building blocks of skilled reading.

Locations

Country	Name	City	State
United States	Stanford University	Stanford	California

Sponsors (1)

Lead Sponsor	Collaborator
Stanford University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	White matter plasticity	Change in white matter mean diffusivity measured with diffusion MRI	Change between baseline (within 2 weeks pre-intervention) and post-intervention (within 2 weeks post-intervention)
Primary	White matter plasticity	Change in white matter mean diffusivity measured with diffusion MRI	Change between baseline (within 2 weeks pre-intervention) and post-intervention (1 year follow-up)