Clinical Trials Logo

Clinical Trial Summary

Dupuytren's disease is a frequent hereditary disease in Northern Europe. It is a degenerative disease affecting the palmar aponeurosis of the hand. It develops a progressive contractile fibrosis which cuts the hypodermic fatty tissue, adheres to the skin and the phalanges, gradually bending the affected rays, resulting in significant functional impotence. Various medical and surgical treatments are available.

Clinical Trial Description

Among these treatments, none to date can eliminate recurrences, which are still too frequent. Open aponeurectomy (consisting of surgical curettage of the fibrotic cords) remains for the moment the reference technique for treating Dupuytren's disease, with recurrences (between 12 and 39%), but less frequent than the needle technique (50 to 85%). Could the addition of adipose tissue in the resection areas of Dupytren's fibrosis reduce the rate of recurrence (by the inhibitory action of ADCs on myofibroblasts) in addition to reconstructing the hypodermis in the cavity left by the resection of the cords and improving the quality of the scars? Let us insist on the fact that this is a homotopic and homologous adipose tissue graft, in closed circuit without denaturation or adjuvant products. Since, to our knowledge, no other team has used "lipofilling" as an adjuvant treatment to the open resection technique of Dupuytren's cords (aponeurectomy), we first conducted a clinical feasibility and safety study on 70 patients between 2012 and 2017 (currently being published by Springer Editions). We now wish to conduct a prospective comparative study between patients operated by aponeurectomy WITH (experimental group) and WITHOUT (control group) addition of autologous adipose tissue in the resection areas of Dupuytren's cords. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05067764
Study type Interventional
Source Elsan
Contact Elias SAWAYA, MD
Phone (0)663420278
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date November 1, 2021
Completion date November 1, 2028

See also
  Status Clinical Trial Phase
Recruiting NCT04122313 - Post-contracture Release Radiation for Dupuytren's Disease
Completed NCT01498640 - Retreatment of Recurrent Dupuytren's Contractures Phase 4
Completed NCT01450397 - MRI Results in Dupuytren's Contracture Before and After Injection With Xiaflex Phase 4
Completed NCT03180957 - Repurposing Anti-TNF for Treating Dupuytren's Disease Phase 2
Completed NCT00575458 - Splinting for Dupuytren's Contracture Release N/A
Completed NCT00260429 - Collagenase in the Treatment of Dupuytrens Disease Phase 3
Active, not recruiting NCT02725528 - Evaluation of Xiaflex: Trial of Effectivenss iN Dupuytren's Phase 3
Completed NCT02193828 - Phase 2a Dose-Ranging Study to Evaluate Safety and Effectiveness of AA4500 in Treatment of Dupuytren's Disease Nodules Phase 2
Completed NCT00954746 - Longterm Observational Study in Subjects Treated With AA4500 in AUX-CC-854, 856, 857, 858 & 859 N/A
Enrolling by invitation NCT04874870 - Effectiveness of Splinting After Collagenase Injection Phase 3
Not yet recruiting NCT02294890 - Knee Stiffness in Fibrosis Diathesis N/A
Recruiting NCT04669704 - Effectiveness of a Tele-Rehabilitation Evidence-based Tablet App for Rehabilitation in Traumatic Bone and Soft Injuries of the Hand, Wrist and Fingers. N/A
Active, not recruiting NCT01446432 - Validation of Two New Questionnaires for Dupuytren's Disease N/A
Completed NCT01567397 - Registry of Dupuytren's Contracture Treatment Outcomes N/A
Terminated NCT01226121 - Safety and Efficacy of Delayed Manipulation After Xiaflex Treatment in Subjects With Dupuytren's Contracture Phase 4
Recruiting NCT04164953 - Tolerance and Efficacy Study of Second-line Surgery After Percutaneous Needle Aponeurotomy for Dupuytren's Disease. N/A