Dry Eye Syndromes Clinical Trial
Dry eye syndrome is a highly prevalent ocular disease with an increasing incidence in the
elderly population. Topically administered lubricants are the basis for treatment of this
disease. However, exact information about influence on tear film thickness and corneal
residence time of topical lubricants is still sparse, therefore no ideal treatment regimen
has been found.
Recently a new method for assessment of tear film thickness based on ultra-high resolution
optical coherence tomography (OCT) has become available. The aim of the present study is to
assess the influence on tear film thickness of three different formulations of topical
lubricants, in particular Thealoz Duo® Eye Drops, Optive® Eye Drops and Systane Ultra® Eye
Drops in patients with moderate to severe dry eye disease. In addition, standard tests for
dry eye syndrome, such as the ocular surface disease index (OSDI©), Schirmer I test, corneal
fluorescein staining and determination of tear break up time (BUT) will be performed to
compare the product effects.
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