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Dry Eye Syndromes clinical trials

View clinical trials related to Dry Eye Syndromes.

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NCT ID: NCT04213248 Recruiting - Dry Eye Clinical Trials

Effect of UMSCs Derived Exosomes on Dry Eye in Patients With cGVHD

Start date: February 21, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to determine whether Umbilical Mesenchymal Stem Cells (UMSCs) derived Exosomes could alleviate dry eye symptoms in patients with chronic Graft Versus Host Diseases (cGVHD).

NCT ID: NCT04206020 Completed - Dry Eye Syndrome Clinical Trials

Vehicle-Controlled Study of SkQ1 as Treatment for Dry-eye Syndrome

VISTA-2
Start date: December 20, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate whether SkQ1 Ophthalmic Solution is safe and effective compared to Vehicle for the treatment of the signs and symptoms of dry eye syndrome.

NCT ID: NCT04201574 Completed - Dry Eye Disease Clinical Trials

Phase 1/2a Safety and Efficacy of ALY688 Ophthalmic Solution in Subjects With Dry Eye Disease

Start date: December 16, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

Clinical Trial Evaluating the Safety and Tolerability of ALY688 in Subjects with Dry Eye Disease

NCT ID: NCT04198740 Recruiting - Dry Eye Syndrome Clinical Trials

Proteomic and Metabolomic Lacrimal Fingerprint in Diverse Pathologies of the Ocular Surface

EML-MSO
Start date: February 1, 2020
Phase:
Study type: Observational

This study aims to obtain the lacrimal fingerprint for frequent pathologies of the ocular surface and establish a normative base for each of them.

NCT ID: NCT04184999 Completed - Dry Eye Syndromes Clinical Trials

Effect of Intraoperative Dexamethasone on Post-op Dry Eye

Start date: August 10, 2019
Phase: Phase 4
Study type: Interventional

To compare the signs and symptoms of dry eye after cataract surgery between subjects randomized to receive intraoperative dexamethasone in addition to the use of a standard topical post-op treatment regimen.

NCT ID: NCT04181593 Active, not recruiting - Dry Eye Clinical Trials

Phase 3 Study of the Safety and Efficacy of OmegaD Softgels in the Treatment of Dry Eye Disease

Start date: November 18, 2019
Phase: Phase 3
Study type: Interventional

This is a phase 3 study to evaluate the safety and efficacy of OmegaD softgels for the treatment of dry eye disease. A daily dose of 2 OmegaD softgels dosed orally BID will be compared to 2 placebo softgels (mineral oil ) dosed orally BID for 84 days. Approximately 300 subjects will be evaluated for their signs and symptoms of dry eye disease and for safety throughout the study.

NCT ID: NCT04172961 Recruiting - Dry Eye Clinical Trials

Clinical Efficacy of Two Topical Dry Eye Drops for Central Corneal Stain Clearing Over 90 Days

Start date: February 1, 2020
Phase: Phase 4
Study type: Interventional

This study will be a randomized, double-blind prospective in 3 clinical sites to compare the efficacy of two currently approved topical ophthalmic drops in the clearing central corneal staining in 90 days prior to elective cataract or LASIK surgery.

NCT ID: NCT04165785 Completed - Dry Eye Syndromes Clinical Trials

Efficiency and Changes of Cytokines Expression in Tear After Intense Pulsed Light Treating Dry Eye Disease

Start date: August 20, 2018
Phase: N/A
Study type: Interventional

The aim of the current study is to investigate changes of tear cytokines levels as well as the efficacy and the reduction of demodex infestation after OPT IPL treatment in patients with meibomian gland dysfunction-Associated demodicosis. The effect of OPT IPL will be examined in a study designed as a randomised controlled trial. In the study arm, subjects will undergo 4 treatment sessions, consisting of OPT IPL pulses immediately followed by meibomian gland expression (MGX). In the control arm, subjects will undergo the same treatments, except that the OPT IPL pulses will be disabled. For each subject, the duration of the study will be 2 months , as explained in the detailed description.

NCT ID: NCT04163328 Active, not recruiting - Dry Eye Clinical Trials

Effects of Supplementation With PUFAs and Antioxidants for Contact Lens Discomfort

Start date: September 16, 2022
Phase: Phase 4
Study type: Interventional

HydroEye® is a dietary supplement that contains both EPA and DHA, as well as GLA and ALA in the form of black currant seed oil. It also has vitamins A, E, C, B6, and magnesium, many of which are involved in fatty acid metabolism. In 2013, Sheppard et al. tested HydroEye® in dry eye patients who were not contact lens wearers and found that symptoms and corneal smoothness improved in response to HydroEye® supplementation. To date, HydroEye® has not been assessed in patients with contact lens discomfort; therefore, the purpose of this clinical trial is to determine the efficacy of HydroEye® as a treatment for contact lens discomfort.

NCT ID: NCT04159935 Terminated - Dry Eye Clinical Trials

Investigating iLux Efficacy in Contact Lens Wearers With Evaporative Dry Eye Disease

SHEEPDOG
Start date: November 15, 2019
Phase: Phase 4
Study type: Interventional

The purpose of this clinical trial is to investigate the efficacy of a single iLux® treatment in symptomatic CL wearers who have DED (according to the TFOS DEWS II diagnostic criteria), of the evaporative dry eye disease subtype (EDE).