Drug-resistant Clinical Trial
Official title:
A Clinical Study of Allogeneic Human Adipose-derived Mesenchymal Progenitor Cell Exosomes (haMPC-Exos) Nebulizer for the Treatment of Carbapenem-resistant Gram-negative Bacilli-induced Pulmonary Infection
Evaluate the efficacy and safety of haMPC-Exos treatment with pulmonary infection caused by gram-negative bacilli resistant to carbapenems.
Pulmonary infection is a critical disease threatening human health. With the extensive use of
antibiotics, the incidence of clinical drug resistance has been on the rise significantly in
recent years. Once drug resistance occurs, we will see a high mortality rate due to scarce
therapies and a poor prognosis. It is almost impossible to surmount the severe pulmonary
infection caused by drug-resistant bacteria only by upgrading antibiotics. The commonly used
supportive therapies clinically, such as glucocorticoids and immunomodulators, also lack
forceful medical evidence. Therefore, it is urgent to explore new treatments.
Mesenchymal stem/progenitor cell exosomes are nano-sized vesicles secreted by mesenchymal
stem/progenitor cells under certain conditions, which contain a lot of proteins, lipids and
nucleic acids with tissue repair and immunomodulatory functions.
Mesenchymal stem/progenitor cell exosomes are nano-sized vesicles secreted by mesenchymal
stem/progenitor cells under certain conditions, which contain a lot of proteins, lipids and
nucleic acids with tissue repair and immunomodulatory functions.
Currently, it has been confirmed that stem cells can visibly improve the pathological changes
of lungs caused by infection, lighten pulmonary edema, reduce protein exudation, mitigate
alveolar inflammation, and remove bacteria. Thus, it brings new hope for the treatment of
pulmonary infection caused by extensively drug-resistant bacteria.
Patients were treated, in the research project, with well-suited noninvasive haMPC-Exos
aerosol inhalation, in an attempt to verify the efficacy and safety of haMPC-Exos treatment
with pulmonary infection caused by gram-negative bacilli resistant to carbapenems.
;