Clinical Study Evaluating the Safety of Lactobacillus Probiotic in

Status Recruiting

Clinical Trial Summary

Animal and human studies have brought up evidence supporting Gut microbial disbalance, namely dysbiosis, as a causative factor of epilepsy, especially the refractory form. thus, probiotics might constitute a safe, low-cost, and effective supplementary therapy in patients with DRE. The Lactobacillus population is probiotic bacteria that have a beneficial role in epilepsy. Lactobacillus can influence brain function through the modulation of GABA, as shown in rodent models. Moreover, it has been demonstrated in animal models of epilepsy and in human epileptic patients that probiotic treatment aimed at restoring gut microbiota equilibrium has beneficial effects on epileptic symptoms by increasing GABA in animals and the levels of Bifidobacteria and Lactobacillus in humans.

Clinical Trial Description

This study will be a placebo-controlled, double-blind, and parallel 6-month duration study ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05539287
Study type	Interventional
Source	Tanta University
Contact	Amira Rashdan, Rashdan
Phone	01022677143
Email	amira.rashdan@pharm.tanta.edu.eg
Status	Recruiting
Phase	Phase 2
Start date	September 25, 2022
Completion date	January 2025

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Clinical Study Evaluating the Safety of Lactobacillus Probiotic in Children With Drug Resistant Epilepsy

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms