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the Safety and Efficacy of N-acetyl Cysteine in Children With Drug-Resistant Epilepsy

Drug Resistant Epilepsy Clinical Trial

Official title:
Clinical Study Evaluating the Safety and Efficacy of N-acetyl Cysteine in Children With Drug-Resistant Epilepsy

Clinical Trial Summary

This study aims at investigating the possible efficacy and safety of N-acetyl cysteine as adjuvant therapy in the treatment of drug-resistant epilepsy

Clinical Trial Description

N-acetyl-cysteine (NAC), a glutathione precursor, is proven to activate the nuclear factor E2-related factor 2( Nrf2) in mouse models of status epilepticus, thus inhibiting high mobility group box 1 (HMGB1) cytoplasmic translocation in the hippocampal neural and glial cells and preventing the linkage between oxidative stress and neuroinflammation for which the redox-sensitive protein HMGB1 is central. Therefore,It may be useful as an adjuvant in treating various medical conditions, especially neuropsychiatry. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05485558
Study type Interventional
Source Tanta University
Contact Amira Rashdan, master
Phone 01022677143
Email amira.rashdan@pharm.tanta.edu.eg
Status Recruiting
Phase Phase 2
Start date September 15, 2022
Completion date May 1, 2026
View Details
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