Drug Resistant Epilepsy Clinical Trial
Official title:
Leveraging the Gut Microbiota in Pediatric Refractory Epilepsy: Safety and Feasibility of Oligofructose-enriched Inulin Supplementation for Dysbiosis and Seizure Control
Nearly a third of children with epilepsy are refractory to pharmacotherapy. The ketogenic diet (KD) is a highly effective alternative therapy reducing seizure frequency by 50% in more than half of treated children. The exact mechanisms of KD remain poorly understood, and recent studies have implicated the gut microbiota (GM). This pilot study aims to determine the feasibility of a 12-week dietary intervention with prebiotic fiber in children with epilepsy. The investigators hypothesize that consumption of inulin will alter gut microbiota and may have effects on seizure frequency.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04378075 -
A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy
|
Phase 2/Phase 3 | |
Recruiting |
NCT05928598 -
Goals for Epilepsy Clinic Visits Trial
|
N/A | |
Recruiting |
NCT05539287 -
Clinical Study Evaluating the Safety of Lactobacillus Probiotic in Children With Drug Resistant Epilepsy
|
Phase 2 | |
Not yet recruiting |
NCT04601974 -
Lentiviral Gene Therapy for Epilepsy
|
Phase 1/Phase 2 | |
Completed |
NCT02982824 -
Effect of Magnesium Supplementation for Children With Drug Resistant Idiopathic Epilepsy
|
N/A | |
Recruiting |
NCT05485558 -
the Safety and Efficacy of N-acetyl Cysteine in Children With Drug-Resistant Epilepsy
|
Phase 2 | |
Not yet recruiting |
NCT04553354 -
Cortical Resections in Drug Resistant Epilepsy
|
||
Recruiting |
NCT04999046 -
NaviFUS™ System Neuromodulating Treatment for Patients With Drug Resistant Epilepsy
|
N/A | |
Recruiting |
NCT04714996 -
Efficacy, Safety and Pharmacokinetics of ES-481 in Adult Patients With Drug Resistant Epilepsy
|
Phase 2 | |
Recruiting |
NCT04839601 -
RNS System RESPONSE Study
|
N/A | |
Recruiting |
NCT06059157 -
Epileptogenic Network Visualisation With Advanced MRI
|
N/A | |
Recruiting |
NCT05947656 -
Evaluation of the NaviFUS System in Drug Resistant Epilepsy
|
N/A | |
Recruiting |
NCT05393518 -
Electroclinical Correlation of Anxiety
|
N/A | |
Not yet recruiting |
NCT05555537 -
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy
|
||
Completed |
NCT03419000 -
Circulating microRNAs as Biomarkers of RESPIratory Dysfunction in Patients With Refractory epilePSY
|
N/A | |
Enrolling by invitation |
NCT06341075 -
Real-World Study of Magnetic Resonance-guided Laser Interstitial Thermal Therapy for Drug-resistant Epilepsy
|
N/A | |
Not yet recruiting |
NCT05527093 -
Cartography of Social Cognition Network and Their Alterations in Patients With Epilepsy
|
N/A | |
Recruiting |
NCT05697614 -
The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children
|
Phase 4 | |
Recruiting |
NCT06309251 -
Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients
|
||
Recruiting |
NCT06432907 -
StereoEEG Motor Neuronal Potentials Decoding
|
N/A |