Pain Clinical Trial
Official title:
Evaluation of Efficacy and Safety of Subcutaneous Acetaminophen in Geriatrics and Palliative Care
Subcutaneous perfusion is an underused technique, the effectiveness of which has been
demonstrated.
A number of drugs of different therapeutic classes, including morphine, have a good level of
scientific evidence for use by this route.
Subcutaneous Acetaminophen injection is being used in some medical centers, mainly in Europe,
despite the lack of definite evidence on its efficacy.
This study aims to quantify the degree of effectiveness of subcutaneous Acetaminophen
infusions for pain or fever in Geriatrics and Palliative Care, as well as determining its
safety.
Subcutaneous perfusion is an underused technique, the effectiveness of which has been
demonstrated. It is mainly used in Palliative Care and Geriatrics when a venous line is not
available. It is a simple and comfortable technique that allows to administer solutes and /
or medications continuously or discontinuously in the subcutaneous tissue.
A number of drugs of different therapeutic classes, including morphine, have a good level of
scientific evidence for use by this route.
Subcutaneous Acetaminophen injection is being used in some medical centers, mainly in Europe,
despite the lack of definite evidence on its efficacy. It is sometimes accused of causing
pain at the injection site; it seems that this is not the case if it is infused slowly, over
20 minutes to 30 minutes. There is no report of serious local effects.
The consultation palliative care team at Hôtel-Dieu de France (HDF) has used subcutaneous
Acetaminophen infusions repeatedly without adverse effects since January 2014.
This study aims to quantify the degree of effectiveness of subcutaneous Acetaminophen
infusions for pain or fever in Geriatrics and Palliative Care, as well as determining its
safety.
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