A Retrospective Study on Drug Induced Liver Injury in China

Drug-Induced Liver Injury Clinical Trial

— DILI-R  

Official title:

A Retrospective Epidemiologic Study on Incidence and Treatment Status of Hospitalized Drug Induced Liver Injury Patients in Mainland China

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02407964
• Other study ID #: 2012ZX09303-001
• Status: Completed
• Phase: N/A
• First received: March 31, 2015
• Last updated: October 24, 2016
• Start date: March 2015
• Est. completion date: July 2016

Study information

• Verified date: October 2016
• Source: Drug Induced Liver Disease Study Group
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: National Health and Family Planning Commission
• Study type: Observational

Clinical Trial Summary

This is a multi-center, open-enrollment, retrospective, non-interventional epidemiologic study without any clinical treatment. Its primary objective is to understand 1) incidence of drug-induced liver injury, including incidences among all the hospitalized patient, among patients in department of hepatic diseases, digestive diseases, oncology, hematology etc., individually; 2) epidemiologic characteristics of drug-induced liver injury, including suspected medications, clinical types, histological characteristics, severity and outcomes.

Description:

This is a multi-center, open-enrollment, retrospective, non-interventional epidemiologic study without any clinical treatment. Its primary objective is to understand 1) incidence of drug-induced liver injury, including incidences among all the hospitalized patient, among patients in department of hepatic diseases, digestive diseases, oncology, hematology etc., individually; 2) epidemiologic characteristics of drug-induced liver injury, including suspected medications, clinical types, histological characteristics, severity and outcomes.

It investigates medical records of patients who were hospitalized during 2012 to 2014. Those patients should be diagnosed as drug-induced liver injury, drug-induced liver disease, drug-induced hepatitis, drug-induced hepatocirrhosis, drug-induced hepatic failure, or any other similar diagnosis of drug-induced liver injury nature.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15000
• Est. completion date: July 2016
• Est. primary completion date: May 2016
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Any hospitalized patients who were diagnosed as drug-induced liver injury, drug-induced liver disease, drug-induced hepatitis, drug-induced hepatocirrhosis, drug-induced hepatic failure, or any other similar diagnosis of drug-induced liver injury nature.

• The drug-induced liver injury and similar diagnosis were not excluded the possibility of drug-induced nature.

Exclusion Criteria:

• Confirmed non-drug induced liver injury.

• Insufficient clinical data supporting the diagnosis of drug-induced liver injury.

• Liver injury resulted from poisons and chemicals.

Study Design

Time Perspective: Retrospective

Related Conditions & MeSH terms

• Drug-Induced Liver Injury
• Wounds and Injuries

Locations

Country	Name	City	State
China	Department of gastroentrology of Ankang city central hospital	Ankang
China	Department of gastroenterology of Anqing municipal hospital	Anqing
China	Department of infectious disease of Anqing municipal hospital	Anqing
China	Department of tuberculosis of Baoding infectious disease hospital	Baoding
China	Department of gastroentrology,the third hospital of PLA	Baoji
China	Department of infectious disease of Baoji No.2 people's hospital	Baoji
China	Department of infectious disease,the third hospital of PLA	Baoji
China	Department of tuberculosis,the third hospital of PLA	Baoji
China	Department of lymph&breast of Baotou tumor hospital	Baotou
China	Department of breast disease,Tongzhou matermal&child health hospital of Beijing	Beijing
China	Department of gastroenterology of Beijing Huairou hospital	Beijing
China	Department of Hepatology of Beijing Ditan Hospital Capital Medical University	Beijing
China	Department of hepatology of Peking university people's hospital	Beijing
China	Department of infection of Peking university first hospital	Beijing
China	Non infedtious liver disease diagnosis and treatment center,302 military hospital of China	Beijing
China	Department of gastroenterology,the first affiliated hospital of Bengbu medical college	Bengbu
China	Department of infectious disease,the first affiliated hospital of Bengbu medical college	Bengbu
China	Department of infectious disease,the No.123 hospital of PLA	Bengbu
China	Department of gastroenterology of Cangzhou central hospital	Cangzhou
China	Department of gastroenterology,the fourth hospital of Jilin university	Changchun
China	Department of infectious disaese,the fourth hospital of Jilin unversity	Changchun
China	Department of infectious disease of Changchun infectious disease hospital	Changchun
China	Department of rhenmatism,the affiliated hospital to Changchun University of Chinese medicine	Changchun
China	Department of infectious disease,people's hospital Changji hui autonomous prefecture Xinjiang	Changji
China	2st department of hepatology,the first hospital of Changsha	Changsha
China	5st internal meidcine of Hunan chest hospital	Changsha
China	Department of breast disease,the affiliated cancer hospital of Xiangya school	Changsha
China	Department of infectious disease of Hunan provincial people's hospital	Changsha
China	Department of infectious disease of Xiangya hospital central south university	Changsha
China	Department of infectious disease,the second Xiangya hospital of central south university	Changsha
China	Department of infectious disease,the third Xiangya hospital of central south university	Changsha
China	Department of tuberculosis of Changsha central hospital	Changsha
China	Department of infectious disease,Heping hospital affiliated to Changzhi medical university	Changzhi
China	Department of hepatology of Chengdu tenth people's hospital	Chendu
China	Department of gastroenterlogy,affiliated hospital of Chenfdu University	Chengdu
China	Department of gastroenterology,the 416th hospital of CNNC	Chengdu
China	Department of gastroenterology of Chenzhou No.1 people's hospital	Chenzhou
China	Department of hepatology of Chenzhou No.2 people's hospital	Chenzhou
China	Department of infectious disease,the fourth people's hospital of Chenzhou	Chenzhou
China	Department of infectious disease,the people's hospital of Chizhou	Chizhou
China	Department of hepatology,Chongqing hospital of TCM	Chongqing
China	Department of infectious disease of southwest hospital	Chongqing
China	Department of infectious disease,the second affiliated hospital of Chongqing medical university	Chongqing
China	Department of gastroenterology of Daqing oilfield general hospital	Daqing
China	Department of infectious disease of Daqing second hospital	Daqing
China	Department of hepatology of Datong fourth people's hospital	Datong
China	Department of gastroenterology,Qilu hospital of Shandong university	Dongying
China	Department of infectious disease ,Shengli hospital of Shengli oilfield administration	Dongying
China	Department of infectious disease of Shengli oilfield general hospital	Dongying
China	Department of infectious disaese of Erdos second people's hospital	Erdos
China	Department of oncology of Jungar Banner central hospital	Erdos
China	Department of infectious disease of Shanxi province Fenyang hospital	Fenyang
China	Department of infectious disease of Foshan first people's hospital	Foshan
China	Department of infectious disease of Fujian province Fuqing city hospital	Fuqing
China	Department of hepatologym,No.2 people's hospital of Fuyang	Fuyang
China	Department of hepatic-biliary medicine,Fuzhou general hospital of Nanjing military command	Fuzhou
China	Department of hepatic-biliary medicine,No.476 hospital of PLA	Fuzhou
China	Department of hepatology of Fuzhou infectious disease hospital	Fuzhou
China	Department of digestive of Guangdong general hospital	Guangdong
China	Deaprtment of gastroenterology of Guangzhou first people's hospital	Guangzhou
China	Department of gastroenterology of Guagdong general hospital	Guangzhou
China	Department of gsatroenterology of Sun Yat-sen memorial hspital, Sun Yat-sen university	Guangzhou
China	Department of infectious disease of Guangzhou women&children medical center	Guangzhou
China	Department of infectious disease,Nanfang hospital of southern medical university	Guangzhou
China	Department of science education&information of Guangzhou Huiai hospital	Guangzhou
China	Department of hematology,the affiliated hospital of Guiyang medical university	Guiyang
China	Department of infectious disease of Guizhou provincial people's hospital	Guiyang
China	Department of infectious disease,the affiliated hospital of Guiyang medical university	Guiyang
China	10st department of internal medicine of Heilongjiang province center for tuberculosis control and prevention	Haerbin
China	1st mepartment of internal medicine Heilongjiang province center for tuberculosis control and prevention	Haerbin
China	4st department of internal medicine of Heilongjiang province center for tuberculosis control and prevention	Haerbin
China	5st department of internal medicine of Heilongjiang province center for tuberculosis control and prevention	Haerbin
China	7st department of internal medicine of Heilongjiang province center for tuberculosis control and prevention	Haerbin
China	8st department of internal medicine of Heilongjiang province center for tuberculosis control and prevention	Haerbin
China	9st department of internal medicine of Heilongjiang province center for tuberculosis control and prevention	Haerbin
China	Department of infectious disease,No.211 hospital of PLA	Haerbin
China	Department of infectious disease,the first affiliated hosptal of Haerbin medical university	Haerbin
China	Department of infection of Hainan general hospital	Hainan
China	Department of infectious disease of Hangzhou Xiaoshan district first people's hospital	Hangzhou
China	Department of infectious disease of Sir Run Run Shaw hospital,Zhejiang unicersity school of medicine	Hangzhou
China	1st department of respiration of Hanzhong second people's hospital	Hanzhong
China	Department of infection of Hanzhou first people's hospital	Hanzhou
China	Department of gastroenterology,the first affiliated hospital of Anhui medical university	Hefei
China	Department of infectious disease of Anhui provincial hospital	Hefei
China	Department of infectious disease of Hefei infectious disease hospital	Hefei
China	Department of infectious disease,No.105 hospital of PLA	Hefei
China	Department of infectious disease,the first affiliated hospital of Anhui university of Chinese medicine	Hefei
China	Department of hematology of First affiliated hospital,Heilongjiang university of Chinese medicine	Heilongjiang
China	Department of infectious disease,the first affiliated hospital of university of south China	Hengyang
China	Department of hepatology of Hohhot second hospital	Hohhot
China	Department of hepatology of Huai'an No.4 people's hospital	Huai'an
China	department of oncology,Huaiyin hospital of Huai'an city	Huai'an
China	Department of infectious disease,people's hospital of Puluo county	Huizhou
China	Department of oncology,people's hospital of Puluo county	Huizhou
China	Department of infectious disease of Yili friendship hospital	Ili
China	Department of gastroenterology of inner mongolia forestry general hospital	Inner Mongolia
China	Department of hepatology of Inner Mongolia international Mongolian medicine hospital	Inner Mongolia
China	Department of hepatology of No.253 hospital of the PLA	inner Mongolia
China	Department of infection, the affiliated hospital of inner mongolia medical hospital	Inner Mongolia
China	Department of infection,the first affiliated hospital of Baotou medical university	Inner Mongolia
China	Department of infectious disease of inner mongolia people's hospital	Inner Mongolia
China	Department of tuberculosis of The Inner Mongolia Autonomous Region fourth hospital	Inner Mongolia
China	Department of hematology, first affiliated hospital of Jiamusi university	Jiamusi
China	Internal medicine,the 404 hospital of China national nuclear	Jiayuguan
China	Department of gastroenterology of Beihua university affiliated hospital	Jilin
China	Department of gastroenterology,hepatology hospital of Jilin province	Jilin
China	Department of gastroentrology of Jilin integrated TCM&western medicine hospital	Jilin
China	Department of hepatology,hepatology hospital of Jilin province	Jilin
China	Department of hepatology,the first hospital oof Jilin university	Jilin
China	Department of infectious disease of Beihua university affiliated hospital	Jilin
China	1st department of hepatology of Jinan hospital for infectious disease	Jinan
China	Department of endocrinology of Shangdong provincial hospital	Jinan
China	Department of gastroenterology of Jinan central hospital	Jinan
China	Department of gastroenterology,Qilu hospital of Shandong university	Jinan
China	Department of gastroenterology,the second hospital of Shandong university	Jinan
China	Department of hepatology of Shandong province Qianfoshan hospital	Jinan
China	Department of hepatology of Shandong provincial hospital of Chinese medicine	Jinan
China	Department of rheumatology of Shandong provincial hospital	Jinan
China	Internal medicine of Jinan city Lixia district people's hospital	Jinan
China	Department of infectious disease of Jincheng anthracite mining group general hospital	Jincheng
China	Department of infectious disease of Zezhou county people's hospital	Jincheng
China	2st department of hepatology of Jingmen No.2 people's hospital	Jingmen
China	Department of gastroenterology of Jingmen No.1 people's hospital	Jingmen
China	Department of gastroenterology ward 2 of Jingmen No.1 people's hospital	Jingmen
China	Department of infectious disease of Jingmen No.2 people's hospital	Jingmen
China	1st internal medicine of Jingzhou hospital for infectious disease	Jingzhou
China	Department of infectious disease of Jingzhou central hospital	Jingzhou
China	Department of gastroenterology of Jinzhong City Yuci district people's hospital	Jinzhong
China	Department of gastroenterology of Qixian county people's hospital	Jinzhong
China	Department of gastroenterology,the second people's hospital of Jinzhong	Jinzhong
China	Department of gastroentrology,the first people's hospital of Jinzhong	Jinzhong
China	Department of infectious disease,the first affiliated hospital of Henan university	Kaifeng
China	Department of infectious disease of Kashgar prefecture first people's hospital	Kashgar
China	Department of gastroenterology of Xishan district people's hospital	Kunming
China	Department of gastroenterology of Yunnan first people's hospital	Kunming
China	Department of gastroenterology,the first affiliated hospital of Kunming medical university	Kunming
China	Department of gastroentrology,the first hospital of Kunming	Kunming
China	Department of infectious disease,Kunming general hospital of Chengdu military	Kunming
China	Department of infectious disease,the first affiliated hospital of Kunming medical university	Kunming
China	Department of rheumatology of Yunnan first people's hospital	Kunming
China	Hepatology center,the second affiliated hospital of Kunming medical university	Kunming
China	Department of hepatology, Gansu provincial hospital of TCM	Lanzhou
China	Department of infectious disease of Lanzhou military general hospital	Lanzhou
China	Department of infestious disease,the first hospital of Lanzhou university	Lanzhou
China	outpatient of pulmonary hospital of Lanzhou	Lanzhou
China	Department of infectious disease of Leqing people's hospital	Leqing
China	Department of hepatology of Liaocheng city infectious disease hospital	Liaocheng
China	Department of hepatology &respiration of Linfen infectious disease hospital	Linfen
China	Department of endocrinolnogy of Linyi people's hospital	Linyi
China	Department of hepatology of Linyi people's hospital	Linyi
China	Department of tuberculosis of Linyi people's hospital	Linyi
China	Department of gastroenterology of Lu'an people's hospital	Lu'an
China	Department of gastroenterology of Luoyang third people's hospital	Luoyang
China	Department of infectious disease of Luoyang central hospital	Luoyang
China	Department of infectios disease,the affiliated hospital of southwest hospital	Luzhou
China	Department of hepatology ward 1 of Mudanjiang Kangan hospital	Mudanjiang
China	Department of hepatology ward 2 of Mudanjiang Kangan hospital	Mudanjiang
China	Department of hepatology wardf 10 of Mudanjiang Kangan hospital	Mudanjiang
China	Department of hepatology wardf 3 of Mudanjiang Kangan hospital	Mudanjiang
China	Department of hepatology wardf 4 of Mudanjiang Kangan hospital	Mudanjiang
China	Department of hepatology wardf 9 of Mudanjiang Kangan hospital	Mudanjiang
China	Department of tuberculosis of ward 11 of Mudanjiang Kangan hospital	Mudanjiang
China	Department of tuberculosis ward 5 of Mudanjiang Kangan hospital	Mudanjiang
China	Department of tuberculosis ward 6 of Mudanjiang Kangan hospital	Mudanjiang
China	Department of tuberculosis ward 7 of Mudanjiang Kangan hospital	Mudanjiang
China	Department of tuberculosis ward 8 of Mudanjiang Kangan hospital	Mudanjiang
China	Department of gastroenterology of Jiangxi provincial people's hospital	Nanchang
China	Department of gastroenterology of the second affiliated hospital to Nanchang university	Nanchang
China	Department of tuberculosis of Jiangxi provincial chest hospital	Nanchang
China	Deparment of oncology, Nanjing hospital of TCM	Nanjing
China	Department of hematology of Nanjing Jiangning hospital	Nanjing
China	Department of hematology, Jiangsu province hospital of TCM	Nanjing
China	Department of hepatology,No.81 hospital of PLA	Nanjing
China	Department of infection of Jiangsu province hospital	Nanjing
China	Department of infection of Nanjing drum tower hospital	Nanjing
China	Department of infection,the second hospital of Nanjing	Nanjing
China	Department of infectious disease of Nanjing Jiangbei people's hospital	Nanjing
China	Department of infectious,Jiangsu procince hospital of TCM	Nanjing
China	Department of oncology , Jiangning hospital of Nanjing city	Nanjing
China	Department on tuberculosis of Nanjing chest hospital	Nanjing
China	Department of gastroenterology,the first affiliated hospital of Guangxi medical university	Nanning
China	Department of hepatology,the first affiliated hospital of Guangxi university of Chinese medicine	Nanning
China	Department of oncology,the first affiliated hospital of Guangxi university of Chinese medicine	Nanning
China	Department of gastroenterology of Ningbo medical treatment center Lihuili hospital	Ningbo
China	Department of gastroenterology,Yinzhou hospital affiliated to medical school of Ningbo university	Ningbo
China	Department of hematology of Ningbo medical treatment center Lihuili hospital	Ningbo
China	Department of hepatology of Ningbo No.2 hospital	Ningbo
China	Department of hepatology,No.113 hospital of PLA	Ningbo
China	Department of psychiatry of Ningbo Kangning hospital	Ningbo
China	Department of tuberculosis of Pingdingshan third people's hospital	Pingdingshan
China	Department of gastroenterology of Jiangxi Pingxiang people's hospital	Pingxiang
China	Department of gastroenterology,Pingxiang city hospital of Chinese medicine	Pingxiang
China	Department of infedtious disease of Pingyang county hospital of Chinese medicine	Pingyang
China	Department of infectious disease,Puyang oilfield general hospital	Puyang
China	Department of tuberculosis,the fifth people hospital of Puyang	Puyang
China	Department of digestive,the affiliated hospital of Qingdao university	Qingdao
China	Department of endocrinology,the affiliated hospital of Qingdao university	Qingdao
China	Department of gastroenterology of Qingdao municipal hospital	Qingdao
China	Department of hepatology,the affiliated hospital of Qingdao university	Qingdao
China	Department of digestive of Qinghai provincial people's hospital	Qinghai
China	Department of hepatology,Qinghai province hospital for infectious disease	Qinghai
China	Deqpartment of gastroenterology of Qinghai university affiliated hospital	Qinghai
China	Department of gastroenterology,the third hosital of Qinhuangdao	Qinhuangdao
China	Department of hepatology,the third hospital of Qinhuangdao	Qinhuangdao
China	Department of infectious disease of Qiqihar infectious disease hospital	Qiqihar
China	Department og gastroenterology,the first hospital of Qiqihar city	Qiqihar
China	Department of infectious disease of Ruian people's hospital	Ruian
China	Department of gastroenterology of Sanmenxia central hospital	Sanmenxia
China	Department of hematology of Sanmenxia central hospital	Sanmenxia
China	Department of infectious disease of Sanmenxia central hospital	Sanmenxia
China	Department of gastroenterology,No.301 hospital Sanya branch	Sanya
China	Clinical research center for tuberculosis of Shanghai pulmonary hospital	Shanghai
China	Department of Digestive Diseases of Shanghai Tongji Hospital	Shanghai
China	Department of Digestive Diseases of The Renji Hospital	Shanghai
China	Department of digestive of Shanghai Tongji hospital	Shanghai
China	Department of gastroenterolgy of Huadong hispital affiliated to Fudan university	Shanghai
China	Department of gastroenterology,the affiliated Zhongshan hospital of Fudan university	Shanghai
China	Department of hepatocirrhosis of Shuguang hospital affiliated Shanghai University of T.C.M	Shanghai
China	Department of hepatology of No.85 hospital of PLA	Shanghai
China	Department of infection of No.85 hospital of PLA	Shanghai
China	Department of Infection of Ruijin Hospital Shanghai Jiaotong University School of Medicine	Shanghai
China	Department of infectious disease of Longhua hospital affiliated to Shianghai univesity of Chinese medicine	Shanghai
China	Department of infectious disease of Shanghai Songjiang district people's hospital	Shanghai
China	Department of infectious disease of Tongren hospital	Shanghai
China	Department of infectious disease,Huashan hospital affiliated to Fudan university	Shanghai
China	Department of oncology of Shanghai Putuo district central hospital	Shanghai
China	Department of oncology of the sixth people's hospital affiliated to Shanghai Jiaotong university	Shanghai
China	Department of pediatrics of Shanghai first people's hospital Songjiang branch	Shanghai
China	Department of digestive of the second affiliated hospital of Xi'an jiaotong university	Shangxi
China	Department of infection of the second affiliated hospital of Xi'an jiaotong university	Shangxi
China	Department of gastroenterology of Shanluo central hospital	Shanluo
China	Department of infectious disease of Shanluo central hospital	Shanluo
China	Department of infectious disease of Shaoxing central hospital	Shaoxing
China	Department of infectious disease of Shaoyang central hospital	Shaoyang
China	Department of infectious disease,Shengjing hospital of China medical university	Shenyang
China	Department of hepatology of Shenzhen third people's hospital	Shenzhen
China	Department of infectious disease of Shenzhen third people's hospital	Shenzhen
China	Department of pulmonary dedicine of Shenzhen third people's hospital	Shenzhen
China	Department of gastroenterology of Hebei general hospital	Shijiazhuang
China	Department of gastroenterology,the first hospital of Hebei medical university	Shijiazhuang
China	Department of hematology,the first hospital of Hebei medical university	Shijiazhuang
China	Department of hepatology,the first hospital of Hebei medical university	Shijiazhuang
China	Department of hepatology,the third hodpital of Hebei medical university	Shijiazhuang
China	Department of tuberculosis of Hubei province chest hospital	Shijiazhuang
China	2st department of gastroenterology of Shiyan people's hospital	Shiyan
China	Department of infectious disease of Dongfeng company general hospital	Shiyan
China	Department of infectious disease of Taihe hospital	Shiyan
China	Department of tuberculosis of Xiyuan hospital of Shiyan city	Shiyan
China	Department of infestious disease,the first people's hospital of Shunde	Shunde
China	Department of gastroenterology of Songyuan central hospital	Songyuan
China	Department of hepatology of Jilin oilfiled general hospital	Songyuan
China	Department of infectious disease of Suzhou municipal hospital	Suzhou
China	Department of infectious disease,the fifth people's hospital of Suzhou	Suzhou
China	Department of i fectious disease of Taian city central hospital	Taian
China	Department of tuberculosis of Taian cancer hospital	Taian
China	1st department of tuberculosis of Taiyuan fourth people's hospital	Taiyuan
China	Department of gastroenterology,the second hospital of Shanxi medical university	Taiyuan	Shanxi
China	Department of hepatology,Shanxi provincial hospital of Chinese medicine	Taiyuan
China	Department of tuberculosis of Taiyuan fourth people's hospital	Taiyuan
China	Department of hematology&oncology,Taizhou hospital of Zhejiang province	Taizhou
China	Department of infectious disease of Tianchang people's hospital	Tianchang
China	Department of hepatology of Tianjin first hospital	Tianjin
China	Department of hepatology of Tianjin third central hospital	Tianjin
China	Department of hepatology,first teaching hospital of Tianjin university	Tianjin
China	Department of hepatology,The affiliated hospital of logistics university of people's armed police force	Tianjin
China	Department of oncology of Tianjin medical university general hospital	Tianjin
China	Department of rheumatology of Tianjin first center hospital	Tianjin
China	Department of infestious disaese of Tibet autonomous prefecture people's hospital	Tibet
China	1st department of oncology of Tonghua central hospital	Tonghua
China	3st department of oncology of Tonghua central hospital	Tonghua
China	Department of oncology of Tonghua second people's hospital	Tonghua
China	Department of oncology&hematology of Tonghua people's hospital	Tonghua
China	Department of infectious disease of Tongliao infectious disease hospital	Tongliao
China	Department of hepatology of The Xinjiang production and construction Corps hospital	Urumqi
China	Department of infectious disease of URUMQI friendship hospital	Urumqi
China	2st department of tuberculosis of Weifang No.2 people's hospital	Weifang
China	Department of gastroenterology of Weifang people's hospital	Weifang
China	Department of gastroenterology of Weihai central hospital	Weihai
China	Department of gastroenterology of Weihai municipal hospital	Weihai
China	Department of infectious disease of Weinan central hospital	Weinan
China	Department of infectious disease,the first people's hospital of Wenling	Wenling
China	Department of hematology of the first affiliated hospital of Wenzhou medical university	Wenzhou
China	Department of infectious disease of Wencheng county people's hospital	Wenzhou
China	Department of infectious disease,Wenshou hospital of Chinesemedicine	Wenzhou
China	Department of oncology of Wuhai people's hospital	Wuhai
China	1st internal medicine of Wuhan institute for tuberculosis control	Wuhan
China	3st internal medicine of Wuhan institute for tuberculosis control	Wuhan
China	4st internal medicine of Wuhan institute for tuberculosis control	Wuhan
China	5st internal medicine of Wuhan institute for tuberculosis control	Wuhan
China	Departmeent of gastroenterology of fifth hodpital in Wuhan	Wuhan
China	Department of gastroenterology of Wuhan integrated TCM&western medicine hospital	Wuhan
China	Department of gastroenterology of Wuhan union hospiital	Wuhan
China	Department of gastroenterology,the central hospital of Wuhan	Wuhan
China	Department of gastroenterology,Wuhan general hospital of Guangzhou military	Wuhan
China	Department of hepatology of Wuhan seventh hospital	Wuhan
China	Department of hepatology,Hubei provincial hospital of TCM	Wuhan
China	Department of hepatology,Wuhan general hospital of Guangzhou military	Wuhan
China	Department of infectious disease of Puren hospital	Wuhan
China	Department of infectious disease of Wuhan iron and steel(group) corp. staff hospital	Wuhan
China	Department of infectious disease of Wuhan iron and steel(group) Crop. second staff hospital	Wuhan
China	Department of infectious disease of Wuhan union hospital	Wuhan
China	Department of infectious disease(north fifth ward) of Wuhan medical treatment center	Wuhan
China	Department of infectious disease(north fourth ward) of Wuhan medical treatment center	Wuhan
China	Department of infectious disease(north sixth ward) of Wuhan medical treatment center	Wuhan
China	Department of infectious disease(south second ward) of Wuhan medical treatment center	Wuhan
China	Department of oncology,Renmin hospital of Hubei university	Wuhan
China	Department of tuberculosis(south fifth ward) of Wuhan medical treatment center	Wuhan
China	Department of tuberculosis(south first ward) of Wuhan medical treatment center	Wuhan
China	Department of tuberculosis(south fourth ward) of Wuhan medical treatment center	Wuhan
China	Department of tuberculosis(south sixth ward) of Wuhan medical treatment center	Wuhan
China	Department of gastroenterology,the first affiliated hospital of Wannan medical college	Wuhu
China	Department of oncology of Wuxi No.2 people's hospital	Wuxi
China	1st internal medicine of Shangxi province tuberculosis prevention and treatment institute	Xi'an
China	2st department of gastroenterology of Shaanxi provincial people's hospital	Xi'an
China	3st internal medicine of Shanxi province tuberculosisi prevention and treatment institute	Xi'an
China	Department of gastroenterology of Xi'an children's hospital	Xi'an
China	Department of gastroenterology of Xijing hospital	Xi'an
China	Department of gastroenterology,No.451 hospital of PLA	Xi'an
China	Department of gastroenterology,the first affiliated hospital of Xi'an Jiaotong university	Xi'an
China	Department of infectious disease,the first affiliated hospital of Xiamen university	Xiamen
China	Departmenr of infectious disease,the first people's hospital of Xiangtan city	Xiangtan
China	Department of infectious disease of Xiangtan central hospital	Xiangtan
China	2st department of gastroenterology of Xiangyang central hospital	Xiangyang
China	Department of gastroenterology B zone of Xiangyang No.1 people's hospital	Xiangyang
China	Department of gastroenterology of Xianyang central hosppital	Xianyang
China	Department of infectious disease of Xianyang central hospital	Xianyang
China	Department of infectious disease,the affiliated hospital of Shaanxi university of Chinese medicine	Xianyang
China	Department of tuberculosis of Xianyang central hospital	Xianyang
China	2st department of oncology,Xinjiang Uyghur aotonomous region hospital of Chinese medicine	Xinjian
China	1st department of oncology,Xinjiang Uyghur aotonomous region hospital of Chinese medicine	Xinjiang
China	4st department of tuberculosis,chest hospital of Xinjiang Uyghur aotonomous region of the PRC	Xinjiang
China	Department of hepatology,Xinjiang Uyghur aotonomous region hospital of Chinese medicine	Xinjiang
China	Department of infectious disease of Xinjiang general hospital of CAPF	Xinjiang
China	Department of infectious disease of Xinjiang Uyghur aotonomous region people's hospital	Xinjiang
China	Department of infectious,the first affiliated hospital of Xinjiang medical university	Xinjiang
China	2st department of infectious disease,the first affiliated hospital of Xinxiang medical university	Xinxiang
China	Department of gastroenterology,Xinyu hospital of Chinese medicine	Xinyu
China	Department of science education of Xinzhou city people hospital	Xinzhou
China	Department of infectious disease of Ya'an people's hospital	Ya'an
China	Department of gastroenterology of Yanan university affiliated hospital	Yanan
China	Department of respiration of Yanan university affiliated hospital	Yanan
China	Department of psychiatry of Yanbian brain hospital	Yanbian
China	Department of hepatology of Yancheng second people's hospital	Yancheng
China	Department of infectious disease of Yancheng city No.1 people's hospital	Yancheng
China	Department of gastroenterology of Yangguan coalmine group general hospital	Yangquan
China	Department of digestive of northern Jiangsu people's hospital	Yangzhou
China	Department of infectious disease,the third hospital of Yangzhou city	Yangzhou
China	Department of oncology of Northern Jiangsu peolple's hospital	Yangzhou
China	Department of gastroenterology of Yanji hospital	Yanji
China	Department of gastroenterology of Yichang first people's hospital	Yichang
China	Department of infectious disease of China Gezhouba group central hospital	Yichang
China	Department of infectious disease of Yichang central people's hospital	Yichang
China	Department of infectious,general hospital of Ningxia medical university	Yinchuan
China	Department of hepatology of Yiyang infectious disease hospital	Yiyang
China	Department of infectious disease,the first hospital of Yulin	Yulin
China	Department of hepatology of Yuncheng infectiuos disease hospital	Yuncheng
China	Department of infectious of Yuyao people's hospital	Yuyao
China	1st department of respiration of Zhengzhou sixth people's hospital	Zhengzhou
China	7st department of respiration of Zhengzhou sixth people's hospital	Zhengzhou
China	Department of digestive of Henan provincial people's hospital	Zhengzhou
China	Department of gastroenterology,the fifth affiliated hospital of Zhengzhou	Zhengzhou
China	Department of gastroenterology,the first affiliated hospital of Henan university of TCM	Zhengzhou
China	Department of gastroentrology of Zhengzhou central hospital	Zhengzhou
China	Department of hepatic-biliary meidicine,No.153 hospital of PLA	Zhengzhou
China	Department of infection,the first affiliated hospital of Zhengzhou university	Zhengzhou
China	Department of infectious disaese of Henan provincial people's hospital	Zhengzhou
China	Department of tuberculosis of Zhengzhou 6th people's hospital	Zhengzhou
China	lienic-gastric-hepatic medicine,Zhengzhou hospital of Chinese medicine	Zhengzhou
China	Department of infectious disease of Zhuzhou central hospital	Zhuzhou
China	Department of digestive of Yiyuan county people's hospital	Zibo
China	Department of rheumatology,central hospital of Zibo	Zibo

Sponsors (2)

Lead Sponsor	Collaborator
Drug Induced Liver Disease Study Group	Unimed Scientific Inc.

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	diagnosis of drug-induced liver injury		6 months	No