Drug Hypersensitivity Clinical Trial
Official title:
Construction and Validation of a Simplified Provocation Test for the Diagnosis of Paracetamol Hypersensitivity
Background : Paracetamol (acetaminophen) drug hypersensitivity reactions (DHR) are oonfirmed
in about 10% of alleged cases. The diagnosis is made via an empirical drug provocation test
(DPT).
Objective: Detect eliciting dose thresholds during Paracetamol DPT in order to suggest
optimal step doses and to identify variables and potential risk factors associated with
Paracetamol hypersensitivity.
Methods:This retrospective study, using the survival analysis and the multivariate analysis,
will comprise all patients who attended the allergy service of the University Hospital of
Montpellier from 1996 till 2018 with a clinical history related to Paracetamol DHR, who
underwent Paracetamol DPT and who gave their consent to be included in the study. The
patients are selected from the Drug Allergy & Hypersensitivity Database (DAHD).
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