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Drug Provocation Test (DPT) to Paracetamol — Paracetamol  

Drug Hypersensitivity Clinical Trial

Official title:
Construction and Validation of a Simplified Provocation Test for the Diagnosis of Paracetamol Hypersensitivity

Clinical Trial Summary

Background : Paracetamol (acetaminophen) drug hypersensitivity reactions (DHR) are oonfirmed in about 10% of alleged cases. The diagnosis is made via an empirical drug provocation test (DPT).

Objective: Detect eliciting dose thresholds during Paracetamol DPT in order to suggest optimal step doses and to identify variables and potential risk factors associated with Paracetamol hypersensitivity.

Methods:This retrospective study, using the survival analysis and the multivariate analysis, will comprise all patients who attended the allergy service of the University Hospital of Montpellier from 1996 till 2018 with a clinical history related to Paracetamol DHR, who underwent Paracetamol DPT and who gave their consent to be included in the study. The patients are selected from the Drug Allergy & Hypersensitivity Database (DAHD).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03771118
Study type Observational
Source University Hospital, Montpellier
Contact
Status Completed
Phase
Start date December 1, 2018
Completion date December 30, 2019
View Details
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