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NCT ID: NCT02621320 Completed - Clinical trials for Vitamin D Deficiency

Vitamin D Supplementation in Wheelchair Indoor Athletes

VitD_SCI
Start date: November 2015
Phase: N/A
Study type: Interventional

There is a high prevalence of vitamin D deficiency in Switzerland. In indoor-athletes as well as wheelchair users, vitamin D deficiency occurs even more often. It is well established that vitamin D deficiency has a negative effect on health. However, vitamin D supplementation in individuals with a vitamin D deficiency has a positive effect on muscle performance. In recently published studies with able-bodied subjects, it has been shown that a normal vitamin D level (>75nmol/L) can only be achieved with a high-dose supplementation of vitamin D. The aim of this study is to examine the effect of vitamin D supplementation on exercise performance in wheelchair athletes with vitamin D deficiency . All participants with a vitamin D deficiency are assigned to the intervention group and treated with 6000 IU of vitamin D3 daily over a period of 12 weeks. All participants who have a normal vitamin D level will receive placebo treatment (control group). The physical performance is measured three times at baseline, after six weeks and 12 weeks. The measurements include a Wingate and a dynamometer test.

NCT ID: NCT02149927 Completed - Anesthesia Clinical Trials

Neural Mechanisms of Sevoflurane Induced Anesthesia: an EEG fMRI Study in Healthy Volunteers

Start date: June 2013
Phase: Phase 0
Study type: Interventional

In imaging functional connectivity (FC) analyses of the resting brain, alterations of FC during unconsciousness have been reported. These results are in accordance to recent electroencephalographic studies observing impaired top-down processing during anesthesia. In this study, simultaneous records of functional magnetic resonance imaging (fMRI) and electroencephalogram (EEG) were performed to investigate the causality of neural mechanisms during sevoflurane anesthesia by correlating FC in fMRI and directional connectivity (DC) in electroencephalogram.

NCT ID: NCT01668147 Completed - Drug Effects Clinical Trials

Efavirenz and Ritonavir on Human Brain P-Glycoprotein

Start date: August 2012
Phase: Phase 1/Phase 2
Study type: Interventional

To determine the effects of ritonavir and efavirenz on the activity of P-glycoprotein in human brain.