Executive Dysfunction Clinical Trial
Official title:
Prefrontal Modulation by Repetitive Bilateral Transcranial Direct Current Stimulation (tDCS) in Crack-cocaine Addicted Inpatients.
In this study, eligible crack-cocaine addicted inpatients recruited from specialized clinics
for substance abuse disorder treatment, filling inclusion criteria and not showing any
exclusion criteria, were randomized to receive the repetitive (10 sessions, every other day)
bilateral dorsolateral Prefrontal Cortex (dlPFC: cathodal left / anodal right) tDCS (2
milliamperes, 3x7 cm2, for 20 min) or placebo (sham-tDCS). Craving to the use of
crack-cocaine was examined before (baseline), during and after the end of the tDCS treatment.
Based in our previous data, our hypothesis was that repetitive bilateral tDCS over dlPFC
would favorably change clinical, cognitive and brain function in crack-cocaine addiction and
these would be long-lasting effects.
Before (baseline) and after tDCS or sham-tDCS treatment, subjects were examined:
(1) clinically, regarding craving (obsessive compulsive scale) and relapses to the drug use.
They were followed-up for clinical examination at least 60 days after treatment.
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