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Intervention-Induced Plasticity of Flexibility and Learning Mechanisms in ASD

Autism Spectrum Disorder Clinical Trial

Official title:
Intervention-Induced Plasticity of Flexibility and Learning Mechanisms in ASD

Clinical Trial Summary

This project explores the association between learning and cognitive flexibility by testing whether a cognitive behavioral intervention designed to improve flexibility in ASD changes learning and associated neural activation using model-based functional magnetic resonance imaging (m-fMRI). The study proposes that variability in learning mechanisms is associated with behavioral flexibility and explains differences in adaptive and treatment outcomes. The study employs a longitudinal case-controlled design in 60 14-18 year old youth with ASD at 3 time-points 8 months apart, each including m-fMRI during learning and behavioral measurement of executive and adaptive function. Aim 1 tests the hypothesis that individual variation in learning biases and their neural correlates predicts behavioral flexibility and is stable over time. Aim 2 tests plasticity of learning mechanisms induced by a cognitive-behavioral intervention for flexibility. Aim 3 tests hypothesis about intervention-induced plasticity of neural functional connectivity.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05131659
Study type Interventional
Source Children's National Research Institute
Contact
Status Active, not recruiting
Phase N/A
Start date October 20, 2021
Completion date May 31, 2026
View Details
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