Drug Hypersensitivity Clinical Trial
Official title:
Origin and Function of Eosinophilic Polynuclear During Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome
Drug Hypersensitivity Syndrome or DRESS for "Drug Reaction with Eosinophilia and Systemic Symptoms" is a serious drug allergy which can be life-threatening for patients with serious organ damage. The pathophysiology of DRESS is still not fully understood. In particular, no study has focused on the characterization of eosinophils, while paradoxically eosinophilia is one of the diagnostic criteria. Likewise, there is no data about the origin of eosinophils and few data are available concerning immune polarization of T-cells or the involvement of innate lymphoid cells type 2 in the recruitment of eosinophils. Our preliminary data on increase activation markers membrane expression of cutaneous eosinophils suggest that this approach could allow the identification of endotypes in which eosinophils are involved and contribute to organ damages. The correlation between tissue infiltration of eosinophils and their degree of activation would then justify the development of targeted therapeutic strategies in DRESS syndrome (anti-IL-5 therapy?). The aim of the project is: 1) Evaluate the activation status of circulating and cutaneous eosinophils in patients with DRESS compared with drug induced maculopapular exanthema without or with eosinophilia (but do not fulfill DRESS criteria) and healthy subjects; 2) Understand the pathophysiological mechanisms at the origin of this eosinophilia.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02839551 -
Optimal Doses for Drug Provocation Tests to Beta-lactams
|
N/A | |
| Completed |
NCT00198419 -
Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase)
|
Phase 1 | |
| Completed |
NCT02839811 -
Medical Device for Drug Allergy Diagnosis
|
N/A | |
| Completed |
NCT02983630 -
Allergy Testing of Patients Labeled as Penicillin Allergic
|
N/A | |
| Completed |
NCT00198458 -
Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase)
|
Phase 1 | |
| Completed |
NCT04421638 -
Cephalosporin Hypersensitivity
|
||
| Recruiting |
NCT02031120 -
Management of Drug Hypersensitivity in Children
|
N/A | |
| Completed |
NCT01276314 -
Evaluation of TNF-α Blockade Effect in Patients With Severe Cutaneous Adverse Drug Reactions
|
N/A | |
| Terminated |
NCT00505648 -
Treatment of Hypersensitivity Syndrome (DRESS) With Tegeline® (Human Immunoglobulin)
|
Phase 3 | |
| Completed |
NCT03158831 -
Drug Challenges Without Prior Skin Testing
|
Phase 1 | |
| Completed |
NCT03076749 -
Predictive Models for Betalactam Allergy
|
N/A | |
| Active, not recruiting |
NCT06428162 -
An Evaluation of Healthcare Providers' Adherence to Pharmacovigilance Practices in an African Community
|
||
| Terminated |
NCT02844712 -
Negative Predictive Value of Drug Provocation Tests to Beta-lactams
|
N/A | |
| Completed |
NCT03743220 -
Drug Provocation Test (DPT) to Non Steroidal Anti-inflammatory Drugs (NSAID)
|
||
| Completed |
NCT03771118 -
Drug Provocation Test (DPT) to Paracetamol
|
||
| Not yet recruiting |
NCT06406114 -
Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing
|
Phase 2 | |
| Completed |
NCT05269082 -
A Study to Assess the Hypersensitivity to TAK-880 Compared to Gammagard S/D in Blood of Children, Teenagers and Adults
|
||
| Completed |
NCT04827602 -
Drug Allergy Labels After Drug Allergy Investigation
|