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NCT02896608 Clinical Trial

Neuronal Excitability of HCN1 Channel Mutations in Dravet Syndrome

Dravet Syndrome Clinical Trial

— EXCIDRAH  

Official title:
Neuronal Excitability of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN1) Channel Mutations in Dravet Syndrome

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02896608
Other study ID # AGN_2015_11
Secondary ID
Status Completed
Phase
First received
Last updated
Start date October 29, 2015
Est. completion date October 16, 2019

Study information
Verified date February 2023
Source Fondation Ophtalmologique Adolphe de Rothschild
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study addresses the changes in the axonal excitability parameters. It will compare these changes in patients with early infantile epileptic encephalopathy with HCN1 channel mutation and in control patients, with and without epilepsy.

Recruitment information / eligibility
Status Completed
Enrollment 92
Est. completion date October 16, 2019
Est. primary completion date October 16, 2019
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 15 Years and older
Eligibility Inclusion Criteria: - early infantile epileptic encephalopathy with HCN1 channel mutation - control patients with no neurologic pathology (age, gender and body temperature matched) - epileptic patients (age, gender and body temperature matched) Exclusion Criteria: - pregnant or breast feeding patient

Study Design

Related Conditions & MeSH terms

Intervention

Device:
• measure of neuronal excitability

Locations
Country Name City State
France Fondation Ophtalmologique Adolphe de Rothschild Paris

Sponsors (1)
Lead Sponsor Collaborator
Fondation Ophtalmologique Adolphe de Rothschild

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary hyperpolarizing electrotonus baseline
Primary hyperpolarizing threshold current baseline
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