Clinical Trials Logo
  1. Home
  2. Down Syndrome
  3. NCT01975545
  4. Details
NCT01975545 Clinical Trial

Fluor Varnish With Silver Nanoparticles for Dental Remineralization in Patients With Trisomy 21

Down Syndrome Clinical Trial

Official title:
Efficacy of the Addition of Silver Nanoparticles to a Fluor Varnish in the Remineralization of Temporary Teeth in Patients With Trisomy 21. Randomized Clinical Trial.

Clinical Trial Details — Status: Unknown status

Administrative data
NCT number NCT01975545
Other study ID # MCIC-001
Secondary ID
Status Unknown status
Phase Phase 2
First received September 3, 2013
Last updated March 5, 2014
Start date September 2012
Est. completion date May 2014

Study information
Verified date March 2014
Source Universidad Autonoma de San Luis Potosí
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Patients with trisomy 21 are in greater danger of developing caries. It has been hypothesized that adding silver nanoparticles to fluor varnishes could promote remineralization of the teeth. A split-plot randomized controlled trial will be performed to address this question.

Recruitment information / eligibility
Status Unknown status
Enrollment 20
Est. completion date May 2014
Est. primary completion date April 2014
Accepts healthy volunteers No
Gender All
Age group 1 Year to 6 Years
Eligibility Inclusion Criteria:

- Patients with trisomy 21 diagnosed through caryotype

- Age 1 to 6 years old

- Any sex

- White spot present in both upper anterior teeth

- Parental agreement to participate in the study

Exclusion Criteria:

- Hypersensibility to any of the substances used

- Non cooperating patients

- Caries in enamel or dentine in the upper anterior teeth

- Leukemia or diabetes

- Dental fluorosis present

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Fluor varnish
Dental varnish will be applied to one anterior superior teeth in a random side.
• Fluor varnish with nanoparticles
Dental varnish with silver nanoparticles will be applied to one anterior superior teeth in a random side.

Locations
Country Name City State
Mexico Universidad Autónoma de San Luis Potosí San Luis Potosí

Sponsors (1)
Lead Sponsor Collaborator
Universidad Autonoma de San Luis Potosí

Country where clinical trial is conducted

Mexico, 

Outcome
Type Measure Description Time frame Safety issue
Primary Remineralization Remineralization status will be assessed through laser fluorescence of the tooth with a Diagnodent probe (Diagnodent, Kavo, Madrid, Spain) 3 months
See also
  Status Clinical Trial Phase
Recruiting NCT04854122 - Blood Flow Regulation in Individuals With Down Syndrome - Training Study N/A
Completed NCT04020302 - Self-Monitoring Shopping Intervention N/A
Recruiting NCT01950624 - DS-Connect {TM}: The Down Syndrome Registry
Completed NCT04751136 - the Effect of Cerebrolysin on Physical and Mental Functions of Down Syndrome Phase 2
Completed NCT04767412 - Inspiratory Muscle Training and Physical Fitness in Children With Down Syndrome Randomized Control Trial N/A
Not yet recruiting NCT04037579 - Protocol for a Non-randomized Survey in Down Syndrome People Who Practice Sports. Self and Observers´ Perception.
Completed NCT04536506 - Bobath and Vojta Therapy for DS N/A
Completed NCT02882698 - Performance Analysis in Down Syndrome on Mobile Phone N/A
Completed NCT01791725 - A 4-Week Safety Study of Oral ELND005 in Young Adults With Down Syndrome Without Dementia Phase 2
Completed NCT01808508 - Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome N/A
Terminated NCT00754013 - Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10 Phase 3
Terminated NCT00754052 - Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 11 To 17 Phase 3
Completed NCT01256112 - Parent Supported Weight Reduction in Down Syndrome N/A
Completed NCT01313325 - Hippotherapy to Improve the Balance of Children With Movement Disorders N/A
Completed NCT01594346 - Multicenter Vitamin E Trial in Aging Persons With Down Syndrome Phase 3
Completed NCT05343468 - Life Skills Improved in Children With Down Syndrome After Using Assistive Technology N/A
Suspended NCT05755464 - Evaluation of Patients With Down Syndrome Compliance to Dental Therapy
Recruiting NCT04022460 - Using Personal Mobile Technology to Identify Obstructive Sleep Apnea in Children With Down Syndrome (UPLOAD)
Completed NCT04818437 - Effect of Core Stability Exercises and Balance Training in Postural Control Among Down Syndrome N/A
Completed NCT03192540 - The Impact of an 8-week Supported Exercise Program on Fitness and Symptoms in Adolescents With Down Syndrome N/A