Healthy Clinical Trial
Official title:
In Vivo Study of Neuroinflammation in Tobaccosmoking: a Clinical Positron EmissionTomography (PET) Study of 18 kDa TranslocatorProtein (TSPO) Using [18F]PBR111 (Part A)
Tobacco smoking is associated with multiple and well-recognized adverse health effects. However, the direct effects of smoking on the brain are less well understood. On of the mechanisms that could be associated with tobacco-related brain toxicity is neuroinflammation. PET/CT imaging constitutes an excellent means of assessment of neuroinflammation in vivo, with the quantification of TSPO using [18F]PBR111. Nonetheless, this radiopharmaceutical has not been authorized for human use in Switzerland.
Our study thus includes two parts. Part A involves a dosimetry study (i.e. measure the exposure of the body organs of healthy individuals to radioactivity after the administration of 200 MBq of [18F]PBR111. This is a prerequisite for the authorization of the use of this radiotracer in humans. Next, the main part of this study (part B) involves the comparison of the quantity of TSPO in the brain of otherwise healthy smokers and age- and sex-matched non-smokers. Part A: Primary objective: to establish the exposure of the organs/tissues to a standard radioactive dose (200 MBq) of [18F]PBR111. ;
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