Clinical Trials Logo
  1. Home
  2. DNA Methylation
  3. NCT05442125

First Live Birth Rate With eSET After Preimplantation Methylome Screening (PIMS) Versus Conventional In-vitro Fertilization

DNA Methylation Clinical Trial

Official title:
Whether Using DNA Methylome to Select Embryos Can Increase the Live Birth Rate During Assisted Reproductive Technology: A Multicenter, Randomized , Open-label Clinical Trial.

Clinical Trial Summary

To determine whether using DNA methylome to select embryos can increase the live birth rate.

Clinical Trial Description

The rationale for the study is to establish the risk/benefit ratio of PIMS in women with in vitro fertilization (IVF) treatment, as DNA methylome is a potential biomarker in blastocyst selection in assited reproductive technology (ART). DNA methylation plays an important role during embryogenesis, global abnormal methylome reprogramming often occurs in human embryos, and DNA methylome pattern is associated with live birth rate. However, there is still no technology using DNA methylome as an indicator in preimplantation embryo screening. Recent paper reported that using Pre-implantation Methylome Screening (PIMS) can select embryos with better methylation state and euploid chromosomes. The efficiency of PIMS needs further validation through randomized clinical trial. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05442125
Study type Interventional
Source Shandong University
Contact Yuan Gao, Professor
Phone 0531-86569866
Email gaoyuan@sduivf.com
Status Recruiting
Phase N/A
Start date September 16, 2022
Completion date May 31, 2025
View Details
See also
  Status Clinical Trial Phase
Completed NCT03642574 - Preimplantation DNA Methylation Test (PIMT) in ART N/A
Completed NCT03787849 - Epigenetics in PostOperative Pediatric Emergence Delirium N/A
Recruiting NCT05624827 - The Role of FAM19A4 and Hsa-mir-124 Methylation in Predicting Prognosis of Untreated Cervical Intraepithelial Neoplasia 2 (CIN 2) N/A
Completed NCT05085847 - Effects of Mindfulness-based Intervention on Epigenetic Mechanisms, Cognition Function, Stress Response, and Well-being N/A
Recruiting NCT04646954 - DNA Methylation Testing for the Screening of Uterine Cervical Lesion Phase 3
Recruiting NCT04651946 - Cell-free DNA Methylation for Epithelial Ovarian Cancer Phase 2
Recruiting NCT03961191 - DNA Methylation for Screening Uterine Cervical Lesions: A Case-control Study
Not yet recruiting NCT05779904 - Methylation, mIcrobiome, NUtritional sTatus, and dEvelopment of Stunted Children
Recruiting NCT05791149 - Epigenetic Biomarkers in the Saliva for the Diagnosis of Squamous Cells Carcinoma of the Oral Cavity N/A
Recruiting NCT05801263 - ctDNA Methylation for Epithelial Ovarian Cancer
Recruiting NCT05801276 - ctDNA Methylation for Detecting Ovarian Cancer
Recruiting NCT05290415 - Host DNA Methylation for Endometrial Cancer Screening
Recruiting NCT05290428 - DNA PAX1 and JAM3 Methylation for Cervical Cancer Screening
Recruiting NCT05290922 - DNA CDO1 and CELF4 Methylation for Endometrial Cancer Screening
Recruiting NCT03960879 - DNA Methylation for Screening Uterine Cervical Lesions
Recruiting NCT05737953 - Construction of Molecular Diagnostic Marker Model for Pancreatic Cystic Tumors Based on Pancreatic Cystic Fluid Samples
Recruiting NCT06140992 - PaCIFiC-CUP Classifies Cancer of Unknown Primary
Completed NCT02032628 - DNA Methylation and Cancer Prevention: Duration and Intensity of Exercise N/A
Completed NCT04568512 - DNA Methylation Biomarker for Diagnosis of Cholangiocarcinoma in Patients With Bile Duct Stricture N/A
Completed NCT03227003 - DNA Methylation and 1-C Metabolism Nutrient Intake N/A