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Anti-thymocyte Globulin-induced Immune Senescence — SIGAL  

Disorder Related to Renal Transplantation Clinical Trial

Official title:
Anti-thymocyte Globulin-induced Immune Senescence

Clinical Trial Summary

The aim of the study is to investigate the impact of Anti-Thymocyte Globulin (ATG) on immune senescence. Markers of immune senescence expression is assessed in a prospective cohort of renal transplant recipients the day of transplantation and one year after renal transplantation.

Clinical Trial Description

The anti-thymocyte globulin (ATG) are used in the prevention and treatment of acute rejection in organ transplantation. They are at the origin of a brutal CD4 lymphocyte depletion followed by a gradual recovery of the lymphocyte pool. Nevertheless, CD4 lymphopenia can persist in some patients.

SIGAL study aims to characterize the immune responses of lymphopenic patients (after administration of ATG) in order to identify possible similarities with immunosenescence.The immunosenescence is a complex and profound remodeling of the immune system during life. It is mainly due to thymic involution and repeated antigenic stimulation. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

  • Disorder Related to Renal Transplantation
Clinical Trial Details
NCT number NCT02857907
Study type Observational
Source Centre Hospitalier Universitaire de Besancon
Contact
Status Completed
Phase N/A
Start date April 2010
Completion date January 2013
View Details
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