Proteomics for Chronic Disorder of Consciousness

Status Recruiting

Clinical Trial Summary

Following severe traumatic brain injury, patients may remain unconscious for many years. It is the first proteomic analysis comparing differentially expressed proteins between patients with chronic disorder of consciousness and controls so far. The investigators generated accurate lists of proteomes and identified differences at different disease time courses. The obtained results provide new insight into understanding the molecular mechanisms underlying the chronic disorder of consciousness.

Clinical Trial Description

Background: Patients who awake from severely traumatic brain injury (sTBI) may remain unconscious for many years. Although behavioral assessment and functional imaging are currently used as diagnostic tools, the molecular basis underlying chronic condition has yet to be explored.

Objective:To explore the molecular basis and identify novel biomarkers for the diagnosis and prognosis of patients with chronic disorder of consciousness.

Method: Plasma samples were obtained from patients with chronic disorder of consciousness, and healthy volunteers. A coupled isobaric tag for relative and absolute quantitation (iTRAQ)-based proteomics approach was used to screen differentially expressed proteins (DEPs) between patients and controls. Potential molecular mechanisms were further discussed through bioinformatics analyses. Candidate proteins were validated by enzyme-linked immunosorbent assay (ELISA). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03611166
Study type	Observational
Source	First Affiliated Hospital of Zhejiang University
Contact	Wangxiao Bao, PHD
Phone	(86)15057137653
Email	baowangxiao@zju.edu.cn
Status	Recruiting
Phase
Start date	November 1, 2015
Completion date	January 15, 2020

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05954650` - Clinical Validity of the Minimally Conscious State "Plus" and "Minus"
Suspended	`NCT04244058` - Changes in Glutamatergic Neurotransmission of Severe TBI Patients	Early Phase 1
Not yet recruiting	`NCT05833568` - Five-day 20-minute 10-Hz tACS in Patients With a Disorder of Consciousness	N/A
Recruiting	`NCT05219331` - Hydrocephalus Treatment on Persistent Disorder of Consciousness	N/A
Recruiting	`NCT05706831` - Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases	N/A
Completed	`NCT03114397` - Long-term Effect of tDCS in Patients With Disorders of Consciousness	N/A
Active, not recruiting	`NCT03623828` - Treating Severe Brain-injured Patients With Apomorphine	Phase 2
Active, not recruiting	`NCT05734183` - Multisensorial IMmersive Experiences (MIME) in Disorders of Consciousness	N/A
Recruiting	`NCT05714215` - SECONDs' Italian Translation and Transcultural Validation
Completed	`NCT04035655` - Sub-study of the NEURODOC Project : Neurophysiological Evaluation of a Routine Care Open Label tDCS Session	N/A
Active, not recruiting	`NCT05747170` - Olfactory Stimulation in Severe Brain Injury	N/A
Active, not recruiting	`NCT03826407` - Development of a Point of Care System for Automated Coma Prognosis
Recruiting	`NCT03576248` - CONsciousness Transcranial Electric STimulation	N/A
Recruiting	`NCT05382260` - Personal Music for Disorders of Consciousness	N/A
Not yet recruiting	`NCT05820178` - tDCS and rTMS in Patients With Early Disorders of Consciousness	N/A
Recruiting	`NCT05343507` - Ketamine to Treat Patients With Post-comatose Disorders of Consciousness	Phase 2/Phase 3
Completed	`NCT05536921` - Eye Tracking Technology in the Diagnosis of Neurological Patients
Recruiting	`NCT05740735` - Emotional and Neutral Sounds for Neurophysiological Prognostic Assessment of Critically Ill Patients With a Disorder of Consciousness
Completed	`NCT02647996` - Functional Connectivity Measurement After Severe Traumatic Brain Injury
Completed	`NCT04530968` - Metabolic Abnormalities and Intestinal Microecology in Patients With Chronic Disorders of Consciousness