Proteomics for Chronic Disorder of Consciousness

Status Recruiting

Clinical Trial Summary

Following severe traumatic brain injury, patients may remain unconscious for many years. It is the first proteomic analysis comparing differentially expressed proteins between patients with chronic disorder of consciousness and controls so far. The investigators generated accurate lists of proteomes and identified differences at different disease time courses. The obtained results provide new insight into understanding the molecular mechanisms underlying the chronic disorder of consciousness.

Clinical Trial Description

Background: Patients who awake from severely traumatic brain injury (sTBI) may remain unconscious for many years. Although behavioral assessment and functional imaging are currently used as diagnostic tools, the molecular basis underlying chronic condition has yet to be explored.

Objective:To explore the molecular basis and identify novel biomarkers for the diagnosis and prognosis of patients with chronic disorder of consciousness.

Method: Plasma samples were obtained from patients with chronic disorder of consciousness, and healthy volunteers. A coupled isobaric tag for relative and absolute quantitation (iTRAQ)-based proteomics approach was used to screen differentially expressed proteins (DEPs) between patients and controls. Potential molecular mechanisms were further discussed through bioinformatics analyses. Candidate proteins were validated by enzyme-linked immunosorbent assay (ELISA). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03611166
Study type	Observational
Source	First Affiliated Hospital of Zhejiang University
Contact	Wangxiao Bao, PHD
Phone	(86)15057137653
Email	baowangxiao@zju.edu.cn
Status	Recruiting
Phase
Start date	November 1, 2015
Completion date	January 15, 2020

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