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A Pilot Trial of Topical Thalidomide for the Management of Chronic Discoid Lupus Erythematosus

Discoid Lupus Erythematosus Clinical Trial

Official title:
A Pilot Trial of Topical Thalidomide for the Management of Chronic Discoid Lupus Erythematosus

Clinical Trial Summary

The purpose of this double-masked, pilot trial is to determine whether 20 percent thalidomide ointment is safe and effective for the treatment of chronic discoid lupus erythematosus (CDLE) when used under an occlusive dressing. Seventeen patients with two similar lesions will have lesions randomized to receive either intervention or placebo therapy.

Clinical Trial Description

The purpose of this double-masked, pilot trial is to determine whether 20 % thalidomide ointment is safe and effective for the treatment of chronic discoid lupus erythematosus (CDLE) when used under an occlusive dressing. Seventeen patients with two similar lesions will have lesions randomized to receive either intervention or placebo therapy. ;

Study Design

Endpoint Classification: Safety/Efficacy Study, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00001680
Study type Interventional
Source National Institutes of Health Clinical Center (CC)
Contact
Status Completed
Phase Phase 2
Start date October 1997
Completion date July 2001
View Details
See also
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Completed NCT00625521 - Efficacy and Safety of ASF-1096 Cream 0.5% in the Treatment of Discoid Lupus Erythematosus (DLE) Lesions Phase 2
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Terminated NCT03958955 - Efficacy and Safety of Delgocitinib Cream in Discoid Lupus Erythematosus. Phase 2
Terminated NCT03159936 - Oral Tofacitinib in Adult Subjects With Discoid Lupus Erythematosus (DLE) and Systemic Lupus Erythematosus (SLE) Early Phase 1
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Completed NCT00608673 - Comparing the Therapeutic Efficacy of Pimecrolimus Cream With Betamethasone Cream for Discoid Lupus Erythematosus N/A
Recruiting NCT06261021 - Study to Evaluate the Efficacy of Ruxolitinib 1.5% Cream in Adult Subjects With Discoid Lupus Erythematosus Phase 2
Completed NCT00625157 - Efficacy and Safety of ASF-1096 Cream 0.5% in the Treatment of Discoid Lupus Erythematosus (DLE) Lesions (2) Phase 2