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Diminished Ovarian Reserve clinical trials

View clinical trials related to Diminished Ovarian Reserve.

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NCT ID: NCT04237909 Completed - Clinical trials for Premature Ovarian Failure

Effects of Intraovarian Platelet Rich Plasma in Women With Poor Ovarian Response and Premature Ovarian Insufficiency

Start date: January 27, 2020
Phase: N/A
Study type: Interventional

Reproductive age women diagnosed with poor ovarian response (POR) based on Poseidon criteria and premature ovarian insufficiency (POI) based on ESHRE criteria and with a history of at least one prior failed IVF cycle will be recruited for the study. Antral follicle count (AFC), serum anti-mullerian hormone (AMH), and early follicular phase serum follicle stimulating hormone (FSH) levels will determined at baseline. Autologous blood obtained from peripheral vein will be used to prepare PRP following standard protocols and will be injected to at least one ovary. Ovarian reserve parameters and IVF outcomes will be determined.

NCT ID: NCT03831542 Completed - Clinical trials for Diminished Ovarian Reserve

Effect of Follicular Flushing in Patients With Mono-follicular Growth Undergoing In Vitro Fertilization

Start date: February 19, 2019
Phase:
Study type: Observational

Retrieval of an oocyte from a follicle relies on the release of the cumulus-oocyte-complex (COC) from the follicular wall into the lumen, thereby allowing aspiration by a needle. Flushing the follicle with multiple aspirations from the same follicle is used as a means to increase the ratio of COC per aspirated follicle. Data showed that follicular flushing is not superior to direct aspiration either in normally responding patients or in poor responders undergoing in vitro fertilization (IVF). There is no data in the literature regarding the issue in patients with mono-follicular growth. Direct aspiration or repeatedly flushing the follicle for those with a single follicle will be investigated.

NCT ID: NCT03670407 Recruiting - Clinical trials for Diminished Ovarian Reserve

Follicular Activation by Fragmentation of Ovarian Tissue

FAFOT
Start date: September 1, 2018
Phase: N/A
Study type: Interventional

The primary objective of this study is to assess the chances of increasing the number of antral follicles in ovarian tissue of patients with diminished ovarian reserve by activation of primordial follicles through ovarian cortex fragmentation. Secondary objectives are to assess potential association with the number of oocytes retrieved and pregnancy rates after IVF.

NCT ID: NCT03474120 Recruiting - Clinical trials for Premature Ovarian Failure

Prospective Genetic Study in Patients With Ovarian Insufficiency

Start date: April 20, 2018
Phase:
Study type: Observational

genetic screening and etiological analysis was conducted on patients with ovarian insufficiency and decline in ovarian reserve. All patients were enrolled in the IVF-treated and non-IVF-treated groups, followed up for long-term treatment outcomes and genomic screening.

NCT ID: NCT02099916 Not yet recruiting - Clinical trials for Diminished Ovarian Reserve

Administration of DHEA in Patients With Poor Response to Ovarian Stimulation for IVF

DHEA
Start date: October 2014
Phase: Phase 2/Phase 3
Study type: Interventional

Poor responders to ovarian stimulation represents one of the most frustrating problems in reproductive medicine. The investigators hypothesize that ovarian response of those patients could improve by treating these patients with 25 mg DHEA tid for 12 weeks prior to stimulation.

NCT ID: NCT01614067 Terminated - Infertility Clinical Trials

Delayed Start to Ovarian Stimulation

DOS/DOR
Start date: May 2012
Phase: Phase 4
Study type: Interventional

In couples with infertility secondary to Diminished Ovarian Reserve, the investigators hypothesize that a delayed start (7 day) to ovarian stimulation with an GnRH antagonist (Ganirelix) will improve oocyte maturation and quality, and improve pregnancy outcomes.