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Diminished Ovarian Reserve clinical trials

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NCT ID: NCT06426355 Recruiting - Clinical trials for Diminished Ovarian Reserve

The Effeciency of NMN in Improving IVF/ICSI-ET Pregnancy Outcomes in Patients With DOR

Start date: October 1, 2023
Phase: N/A
Study type: Interventional

The purpose of the study is to understand the effect of nicotinamide mononucleotide (NMN) on patients with diminished ovarian reserve and the outcomes of IVF/ICSI-ET.

NCT ID: NCT06395623 Recruiting - Clinical trials for Diminished Ovarian Reserve

Study of Acupoints in Diminished Ovarian Reserve Based on Biological Characteristics

Start date: March 24, 2024
Phase:
Study type: Observational

Diminished Ovarian Reserve (DOR) is characterized by decreased female fertility, menstrual disorders and perimenopausal symptoms due to sex hormone deficiency or fluctuations. For now, there are no uniform diagnostic criteria or an ideal single detection index for DOR because of its insidious etiology and pathogenesis,theories suggest that there are specific changes in the body surface or acupuncture points in a pathological state. By detecting the biological characteristics of relevant meridian points and exploring the specificity and regularity of it.

NCT ID: NCT06223178 Recruiting - Clinical trials for Diminished Ovarian Reserve

Efficacy of Thumb-tack Needle Treatment for Diminished Ovarian Reserve

Start date: November 3, 2023
Phase: N/A
Study type: Interventional

Diminished Ovarian Reserve (DOR) is characterized as an important cause of infertility. Acupuncture has been extensively used to treat female infertility. This study was conducted to investigate the efficacy of thumb-tack needle,as a new special type of acupuncture and long-lasting treatment modality,in the treatment of DOR.

NCT ID: NCT06096766 Recruiting - Aging Clinical Trials

the Correlation Between Ovarian Function and Serum Biomarkers

Start date: October 25, 2023
Phase:
Study type: Observational

The goal of this observational study is to find differences in serum biomarkers between ovarian function and normal individuals.

NCT ID: NCT06081257 Not yet recruiting - Clinical trials for Diminished Ovarian Reserve

The Effect of "KB-120" Small Molecular Nutrient in Women With Decreased Ovarian Reserve

Start date: October 15, 2023
Phase: N/A
Study type: Interventional

"KB-120" small molecular nutrient is a structural multi-molecular natural nutrient with different components. It is produced from strains and natural plant culture-medium that can be used in food and is designed according to different efficacy of different products by multi-stage solid-liquid complex fermentation technology. The functional directions of the product series involved are: immune function damage repair, intestinal villi damage repair, sperm development machinery damage repair, ovarian function damage repair, liver function damage repair, sleep disorder function damage repair, etc.Previous studies have shown that "KB-120" has good clinical effects on improving the number and function of male germ cells.Luanbao "KB-120" is a compound plant health drink specially for women. This study intends to give "KB-120" small molecule nutrients as nutritional supplement intervention in female patients with ovarian dysfunction, and observe its influence on endocrine function, ovarian reserve function and fertility in patients with ovarian dysfunction.

NCT ID: NCT06072794 Recruiting - Clinical trials for Diminished Ovarian Reserve

A Proof of Concept Study to Evaluate Exosomes From Human Mesenchymal Stem Cells in Women With Premature Ovarian Insufficiency (POI)

VL-POI-01
Start date: October 6, 2023
Phase: Phase 1
Study type: Interventional

The VL-POI-01 study is designed to evaluate the safety and efficacy of human placental mesenchymal stem cell derived exosome treatment in patients with premature ovarian insufficiency (POI) and diminished ovarian reserve.

NCT ID: NCT05847283 Recruiting - Clinical trials for Diminished Ovarian Reserve

DPOS Versus GnRH Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: An RCT

DPOS
Start date: June 22, 2023
Phase: N/A
Study type: Interventional

One of the barriers in patients with diminished ovarian reserve (DOR) is the significantly reduced number of oocytes resulting in fewer oocytes collected and embryos formed. Many ovarian stimulation strategies have been proposed to improve oocyte or embryo quantity which is oocyte accumulation could be a potential option with a comparable success rate and reasonable cost. Progestin-primed ovarian stimulation (PPOS) protocol could be suggested as an alternative method of premature Luteinizing hormone (LH) prevention in IVF. It favors segment Assisted Reproductive Technology (ART) cycles such as frozen embryo transfer (FET), oocyte donor, fertility preservation, and oocyte accumulation set. The protocol is more patient-friendly and affordable than the GnRH antagonist regimen regarding LH suppression during ovarian stimulation. Many PPOS protocols have been proposed in which the three most common agents include Dydrogesterone (DYG), Micronised Progesterone (MIP), and Medroxyprogesterone acetate (MPA). Indeed, DYG seems to have some advantages, including oral administration and safety which has been used in the treatment of threatened abortion. Initial evidence of PPOS protocol suggests that oocyte quantity and quality are comparable with other ovarian stimulation regimens. However, data related to the PPOS protocol has not been well documented, including Dydrogesteron-primed ovarian stimulation (DPOS). There has not been an RCT with a large sample size and well-designed to provide more substantial evidence. A randomized trial to compare the effectiveness of PPOS and GnRH antagonist protocol in IVF is urgently needed.

NCT ID: NCT05790655 Not yet recruiting - Clinical trials for Diminished Ovarian Reserve

Ovarian PRP for Diminished Ovarian Reserve

oPRP
Start date: April 1, 2023
Phase: N/A
Study type: Interventional

This prospective double-blinded randomized placebo control study aims to determine if In Vitro Fertilization (IVF) outcomes are improved by ovarian platelet-rich plasma injections (oPRP) for women diagnosed with diminished ovarian reserve (DOR). Women with DOR notoriously have the lowest chance of pregnancy and live birth compared to age-matched peers with a normal or robust ovarian reserve.

NCT ID: NCT05677828 Completed - Clinical trials for Diminished Ovarian Reserve

SMART Protocol vs Antagonist Protocol in IVF

Start date: February 15, 2022
Phase:
Study type: Observational

This retrospective study aims to assess the effect of adding letrozole in patients who have previously undergone an IVF cycle with either an antagonist or short protocol, with patients who have undergone a second cycle of IVF with an antagonist or short protocol without the addition of letrozole.

NCT ID: NCT05665010 Recruiting - Clinical trials for Diminished Ovarian Reserve

Precise Stratification of Genetic Risk of Ovarian Function Impairment

Start date: November 1, 2021
Phase:
Study type: Observational

Aging is a common problem in human society at present. The fertility decline, perimenopausal symptoms and senile diseases caused by ovarian aging seriously affect women's own health, offspring's health, family and social stability, and endanger national population security. Accurate stratification of genetic risk of ovarian aging has practical significance. Early and accurate identification of high-risk groups of premature ovarian aging can help such women to start early protection of ovarian function, preserve fertility to a greater extent, improve fertility quality, and also be conducive to early prevention and treatment of other systemic diseases and prognosis.