A Pilot Trial of Ranolazine to Treat Patients With Dilated Cardiomyopathy

Status Completed

Clinical Trial Summary

Clinical Trial Description

Recent data suggest that areas of fibrosis and hibernating myocardium develop in patients with non ischemic dilated cardiomyopathy. Ranolazine is a new drug, developed to releave symptoms of angina in patients with stable coronary disease that is not suitable for surgical or percutaneous revascularization. The main mechanism of action of Ranolazine is the inhibition of late I(Na) thus decreasing the Ca++ load in the cardiomyocites. Consequently oxygen consumption also decreases. It has also been shown that in patients with stable coronary disease Ranolazine improves myocardial perfusion as shown with myocardial nuclear imaging. The aim of this trial is to evaluate effects of ranolazine on myocardial perfusion in patients with dilated cardiomyopathy. Primary end-point: To determine wheather Ranolazine improves perfusion of the myocardium in patients with non-ischemic dilated cardiomyopathy. Secondary end-points: To determine wheather Ranolazine improves patients' NYHA functional class, excercise capacity, LV systolic and diastolic function and weather ranolazine affects supraventricular and ventricular arrhythmia occurance/frequency. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02133911
Study type	Interventional
Source	University Medical Centre Ljubljana
Contact
Status	Completed
Phase	Phase 2
Start date	May 1, 2014
Completion date	April 2, 2016

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A Pilot Trial of Ranolazine to Treat Patients With Dilated Cardiomyopathy — RAMP-DCM

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms