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Clinical Trial Summary

Midwall septal fibrosis (MSF) is a common structural abnormality in non-ischaemic dilated cardiomyopathy (DCM) and its presence is believed to increase the risk of malignant ventricular arrhythmias (VA) but the mechanism of arrhythmogenicity is not known. This is especially relevant in DCM patients with MSF and mid-range left ventricular ejection fraction (EF) as they do not currently fulfill criteria for a primary prevention implantable cardioverter defibrillator. Access to the epicardium for electric measurements can enhance our understanding of arrhythmogenicity in DCM but direct epicardial access is invasive. Instead, we will noninvasively combine high resolution 256-lead ECG imaging (ECGi) and latest generation cardiovascular magnetic resonance (CMR) to study the hearts of 60 DCM patients with and without MSF regardless of the EF, and 60 matched healthy volunteers. We recently invented the re-usable and CMR-safe SMART-ECGi vest technology for this purpose. Using supercomputers, we will fuse the collected ECGi/CMR data and run electromechanical simulations of whole-heart activation to non-invasively measure each participant's personalised risk of malignant VA induction. By panoramically mapping the DCM heart in a single beat, we will reveal how MSF perturbs the cardiac activation front potentially leading to life-threatening VA. This has the potential to change the way we risk stratify patients with DCM

Clinical Trial Description

We will be collecting ECG-Imaging data, cardiac MRI scan, blood sampling, clinicodemographic data collection, and resting 12-lead ECG on each participant. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05026112
Study type Observational
Source University College, London
Contact Fiona Chan, MBBS
Phone 02076705702
Email [email protected]
Status Not yet recruiting
Start date October 1, 2021
Completion date October 1, 2024

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