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Diffuse Parenchymal Lung Disease clinical trials

View clinical trials related to Diffuse Parenchymal Lung Disease.

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NCT ID: NCT01948518 Completed - Clinical trials for Pulmonary Hypertension

Effect of Sildenafil on Diffusion Capacity in Patients With PH and Parenchymal Lung Disease

Start date: June 2009
Phase: N/A
Study type: Interventional

The purpose of this study was to investigate the acute effects of sildenafil on diffusion capacity, a commonly performed pulmonary function test, which is used to assess the lungs' gas exchange capability. This study does not assess safety or efficacy of the drug. The study does not have clinical end points. The variables studied are diffusion capacity and 6 minute walk after a single dose of sildenafil. This study has been completed.

NCT ID: NCT01462006 Completed - Clinical trials for Idiopathic Pulmonary Fibrosis

Double-blind Placebo-controlled Pilot Study of Sirolimus in Idiopathic Pulmonary Fibrosis (IPF)

Start date: October 2011
Phase: N/A
Study type: Interventional

Idiopathic pulmonary fibrosis (IPF) is an illness characterized by progressive decline in lung function and premature death from respiratory failure. Fibrocytes are a novel population of bone marrow-derived circulating progenitor cells that have been shown to traffic to the lungs and contribute to fibrosis in animal models of pulmonary fibrosis, and whose numbers correlate with the degree of fibrosis and with survival in human pulmonary fibrosis. The investigators propose to test the hypothesis that therapy with the mTOR inhibitor, sirolimus, reduces the number of circulating fibrocytes in patients with IPF. The investigators propose to test this hypothesis in short-term pilot trial of sirolimus in patients with IPF to determine its effect on the number and phenotype of circulating fibrocytes.

NCT ID: NCT00453713 Completed - Clinical trials for Idiopathic Pulmonary Fibrosis

Race, Ethnicity, and Diffuse Parenchymal Lung Disease

Start date: July 2006
Phase: N/A
Study type: Observational

The purpose of this study is to identify factors that contribute to higher mortality rates among blacks and Hispanics with diffuse parenchymal lung disease.