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Clinical Trial Summary

The purpose of this study is to evaluate the safety and efficacy of BUCY+VP-16 and BUCY myeloablative conditioning regimens in diffuse large B-cell lymphoma undergoing autologous hematopoietic stem cell transplantation.


Clinical Trial Description

Autologous hematopoietic stem cell transplantation (Auto-HSCT) is an effective therapy for diffuse large B-cell lymphoma (DLBCL).BuCY conditioning regimen is a conventional scheme for DLBCL patients undergoing auto-HSCT, but it has a high relapse rate. Etoposide (VP-16) is extensively used in chemotherapy regimen for refractory/relapsed lymphoma. Whether addition of VP-16 could reduce the relapse rate remains unclear.In this study, the safety and efficacy of BUCY+VP-16 and BUCY myeloablative conditioning regimens in DLBCL undergoing auto-HSCT are evaluated. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03229616
Study type Interventional
Source Nanfang Hospital of Southern Medical University
Contact Qifa Liu
Phone +862061641611
Email liuqifa628@163.com
Status Recruiting
Phase Phase 2/Phase 3
Start date July 5, 2017
Completion date June 2020

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