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Conditioning clinical trials

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NCT ID: NCT06385808 Not yet recruiting - Clinical trials for Hematopoietic Stem Cell Transplantation

Efficacy and Safety of MTBF Conditioning Regimen for Salvageable Allo-HSCT in the Treatment of R/R AML

Start date: May 1, 2024
Phase: N/A
Study type: Interventional

The primary objective of this study was to evaluate the efficacy of MTBF conditioning regimen of salvageable allo-HSCT in patients with relapsed or refractory acute myeloid leukemia. The secondary purpose of the study was to observe the safety of MTBF regimen in these patients.

NCT ID: NCT05814731 Not yet recruiting - Conditioning Clinical Trials

Study on the Efficacy and Safety of MA-BUCY2 Conditioning in High-risk AML Patients Underwent Haplo-HSCT

Start date: April 15, 2023
Phase: N/A
Study type: Interventional

According to the 2022 ELN guidelines patients with high-risk acute myeloid leukemia were randomly divided into MA-BUCY2 conditioning group and BuCy2 conditioning group,to evaluate the efficacy and safety of two conditioning regimens in haploidentical hematopoietic stem cell transplantation.

NCT ID: NCT05814718 Not yet recruiting - Conditioning Clinical Trials

Modified BEAM Regimen for T Cell Lymphoma Underwent ASCT

Start date: April 15, 2023
Phase: N/A
Study type: Interventional

A multicenter randomized study on the efficacy and safety of mitoxantrone hydrochloride liposome injection combined with carmustine, etoposide, and cytarabine (modified BEAM protocol) in the pretreatment of T-cell lymphoma underwent autologous stem cell transplantation

NCT ID: NCT05600725 Completed - Cardiomyopathies Clinical Trials

Novel Cardiac Pacing to Initiate Cardiac Remodeling in Heart Failure

Start date: November 2, 2022
Phase: N/A
Study type: Interventional

This project utilizes a novel cardiac pacing approach hypothesized to initiate beneficial cardiac conditioning and remodeling over a period of time.

NCT ID: NCT05453552 Recruiting - Clinical trials for Myelodysplastic Syndrome

G-CSF+DAC+BUCY vs G-CSF+DAC+BF Conditioning Regimen for High-risk MDS Undergoing Allo-HSCT

Start date: July 1, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

Allo-HSCT is the most effective way to cure high-risk MDS patients. At present, the best conditioning regimen for high-risk MDS patients undergoing allo-HSCT remains in discussion. In this prospective study, the safety and efficacy of G-CSF+DAC+BUCY and G-CSF+DAC+BF conditioning regimens in high-risk MDS patients undergoing allo-HSCT are evaluated.

NCT ID: NCT05449899 Recruiting - Clinical trials for Allogeneic Hematopoietic Stem Cell Transplantation

G-CSF+DAC+BUCY vs G-CSF+DAC+BF Conditioning Regimen for Secondary Acute Myeloid Leukemia Undergoing Allo-HSCT

Start date: July 2022
Phase: Phase 2/Phase 3
Study type: Interventional

Allo-HSCT is the most effective way to cure sAML patients. At present, the best conditioning regimen for sAML patients undergoing allo-HSCT remains in discussion. In this prospective study, the safety and efficacy of G-CSF+DAC+BUCY and G-CSF+DAC+BF conditioning regimens in sAML patients undergoing allo-HSCT are evaluated.

NCT ID: NCT04713956 Recruiting - Clinical trials for Myelodysplastic Syndrome

G-CSF+DAC+BUCY vs G-CSF+DAC+BF Conditioning Regimen for RAEB-1,REAB-2 and AML Secondary to MDS Undergoing Allo-HSCT

Start date: January 15, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

Allo-HSCT is the most effective way to cure MDS and AML secondary to MDS. At present, the best conditioning regimen for MDS and AML secondary to MDS undergoing allo-HSCT remains in discussion. In this prospective study, the safety and efficacy of G-CSF+DAC+BUCY and G-CSF+DAC+BF conditioning regimens in RAEB-1, REAB-2 and AML secondary to MDS undergoing allo-HSCT are evaluated.

NCT ID: NCT04123392 Recruiting - Clinical trials for Allogeneic Hematopoietic Stem Cell Transplantation

Decitabine + BUCY vs BUCY Conditioning Regimen for TP53+ Myeloid Tumors Undergoing Allo-HSCT

Start date: October 2019
Phase: Phase 2/Phase 3
Study type: Interventional

Recent studies have demonstrated that allogeneic hematopoietic stem cell transplantation (allo-HSCT) could be a valuable treatment choice for TP53+ myeloid tumors, such as acute myeloid leukemia and myelodysplastic syndrome. Unfortunately, some patients relapsed after allo-HSCT. In this prospective randomized controlled study, the safety and efficacy of Decitabine + BUCY and BUCY myeloablative conditioning regimens in TP53+ myeloid tumors undergoing allo-HSCT are evaluated.

NCT ID: NCT04098653 Recruiting - Clinical trials for Allogeneic Hematopoietic Stem Cell Transplantation

Decitabine + BUCY vs BUCY Conditioning Regimen for Myeloid Tumors Undergoing Allo-HSCT

Start date: September 2019
Phase: Phase 2/Phase 3
Study type: Interventional

Recent studies have demonstrated that allogeneic hematopoietic stem cell transplantation (allo-HSCT) could be a valuable treatment choice for myeloid tumors, such as acute myeloid leukemia and myelodysplastic syndrome. Unfortunately, some patients relapsed after allo-HSCT. In this prospective randomized controlled study, the safety and efficacy of Decitabine + BUCY and BUCY myeloablative conditioning regimens in myeloid tumors undergoing allo-HSCT are evaluated.

NCT ID: NCT03733327 Recruiting - Clinical trials for Primary Central Nervous System Lymphoma

BUCYE Conditioning Regimen for PCNSL Undergoing Auto-HSCT

Start date: November 2018
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of BUCYE conditioning regimens in primary central nervous system lymphoma undergoing autologous hematopoietic stem cell transplantation.