Influence of the Time of Day in the Effect of Caffeine on Maximal Fat Oxidation During Exercise in Women

Dietary Supplement Clinical Trial

— CIRCAF_WOM  

Official title:

Influence of the Time of Day in the Effect of Caffeine on Maximal Fat Oxidation During Exercise in Women. A Randomized, Crossover, Double-blind, and Placebo-controlled Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05880186
• Other study ID #: UFVitoria_2
• Status: Completed
• Phase: N/A
• Start date: February 9, 2021
• Est. completion date: April 9, 2021

Study information

• Verified date: May 2023
• Source: Universidad Francisco de Vitoria
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Caffeine is a natural stimulant with well-recognized metabolic benefits, however, there is a lack of studies investigating the time-of-day caffeine influence to enhance fat oxidation in women. The aim of this study was to evaluate the influence of the time of the day on the effect of caffeine on maximal rate of fat oxidation during aerobic exercise in women.

Description:

Caffeine is a natural stimulant with well-recognized sports performance benefits. Aside its performance-enhancing effect, caffeine has the potential of increasing fat utilization during aerobic exercise at submaximal intensities, lowering-down the contribution of carbohydrate as a fuel. This property of caffeine may provoke a glycogen-sparing effect in the skeletal muscle and liver for exercise situations where carbohydrate availability may be a challenge. Additionally, the capacity of caffeine to enhance fat utilization during exercise could be of interest for improving health outcomes as it may increase the rate of change in body composition in exercise programs. Maximal fat oxidation rate (MFO) during exercise is a remarkable physiological indicator associated with metabolic flexibility/body weight loss and endurance performance To date, it is unknown if caffeine increases MFO in the same proportion during morning and evening exercise trials in women. For this reason, the aim of the present study was to evaluate the influence of the time of the day on the effect of caffeine on MFO in women. We hypothesised that caffeine would increase MFO during morning and evening exercise and this effect would be of similar magnitude at both times of day.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 14
• Est. completion date: April 9, 2021
• Est. primary completion date: April 9, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• To be non-smokers.

• To have low caffeine intake (i.e., < 50 mg of caffeine per day in the previous 2 months)

• To show no previous history of cardiopulmonary diseases or having suffered musculoskeletal injuries in the previous 6 months.

• To have a regular duration of their menstrual cycle for the previous 6 months.

• To confirm no existence of any type of menstrual disorders such as dysmenorrhea, amenorrhea, or strong symptoms associated with pre-menstrual syndrome.

Exclusion Criteria:

-

Related Conditions & MeSH terms

• Dietary Supplement

Intervention

Dietary Supplement:
• Acute caffeine supplementation
To evaluate the influence of the time of the day (i.e., morning vs evening) on the effect of caffeine on maximal fat oxidation in women.

Locations

Country	Name	City	State
Spain	Universidad Francisco de Vitoria	Pozuelo De Alarcón	Madrid

Sponsors (4)

Lead Sponsor	Collaborator
Universidad Francisco de Vitoria	Camilo Jose Cela University, Universidad de Granada, Universidad Rey Juan Carlos

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	MFO	Maximal fat oxidation during exercise	2-months
Secondary	FATmax	The intensity of exercise that elicits MFO	2-months
Secondary	RPE	Rate of percevied exertion during exercise	2-months
Secondary	FAT AND CHO oxidation	Fat and carbohydrates oxidation	2-months