Dietary Modification Clinical Trial
Official title:
Effect of Nutritional Counseling Associated With the Ingestion of Oat Bran in Hypercholesterolemic Subjects in Secondary Prevention
Dyslipidemia is among the risk factors for cardiovascular diseases (CVD). Is's due to genetic and / or environmental factors such as inadequate dietary pattern. The occurrence of adverse events with statins, added to recent questions about their benefits on hard outcomes, opens a gap for the importance of seeking other forms of treatment of dyslipidemia, particularly in patients for secondary prevention. The consumption of oat bran, beta-glucan source of dietary fibers with supposed action in reducing the absorption of exogenous cholesterol and the endogenous synthesis of it, and source of avenanthramides, phytochemical compounds with alleged antioxidant in lipid membranes, can be effective strategy for secondary prevention of atherosclerotic disease.
Objectives: To evaluate the effect of nutritional counseling associated with the consumption
of oat bran (40g per day) in lowering cholesterol, glucose profile and anthropometric
parameters of subjects in secondary prevention, evaluate the quality of the diet and the
intake of processed foods and ingredients added.
Methods: A randomized block, double-blind, placebo-controlled trial lasting 90 days.
Inclusion criteria: individuals aged greater than 20 years, both genders, with LDL-c equal
or higher than 130mg/dL fasting lipemia. Eligible individuals were considered using oral
lipid-lowering, since the dose reported in the early nutritional intervention was maintained
during the study. Exclusion criteria: patients requiring reduction in daily fluid intake,
supplement use in dietary fiber and gestation / lactation. Data collected: gender; age;
education; drugs; body mass (BM), height, body mass index (BMI), waist circumference (WC),
neck circumference (NC); blood pressure; dietary surveys, total cholesterol (TC), LDL-C,
HDL-cholesterol (HDL-c), triglycerides (TG), fasting glucose (GLU), fasting insulin (INS),
HOMA-IR and QUICK. The diet quality was evaluated at baseline and end of study through the
Diet Quality Index Revised (IQD-R). The sample size calculation was performed from a pilot
study. It came to the need for 63 subjects for each group, oat bran group (GFAV) and placebo
group (GPL). The level of statistical significance was 5% (p <0.05).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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