Dietary Supplements Clinical Trial
Official title:
Bioavailability of Green Tea and Coffee Polyphenols in Healthy Participants
There is little information on the dietary intake, absorption, metabolism and bioavailability
(degree to which a substance becomes available to the target tissues upon administration) of
polyphenols (natural substances present in a variety of foods) in human participants.
This study assessed the bioavailability in healthy participants of polyphenols from 2
supplements containing green tea and green coffee extracts.
Eleven participants were recruited and their habitual diet was assessed to estimate
polyphenol intake. After completing a 24-hour urine collection, participants were given six
green tea extract and three green coffee extract tablets, which they took daily for a period
of 8 weeks. No tablets were taken during the last 4 weeks of the study. Further 24-hour
urines were collected at 2, 4, 8 and 12 weeks.
Participants were required to attend HNR (medical laboratory) the day after each 24hour urine
collection. At these visits, they were asked to bring along their urine collections,
completed documents (urine collection sheet, checklist for tablet intake/side effects) and
any remaining supplements, which were used to assess tablet compliance.
The investigators identified and quantified the amount of polyphenols in the supplement
tablets as well as the amount of polyphenols and their metabolites in urine. The
investigators then evaluated polyphenol bioavailability from the relationship between their
dietary intake and urinary output.
Evidence from this research could inform future intervention studies by providing data on the
bioavailability of green tea and coffee polyphenols, and on the individual differences
related to phenolic intake.
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