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Effects of Genetic Variations in the Response to Brazil Nut Supplementation — SUBRANUT  

Dietary Supplements Clinical Trial

Official title:
Genetic Variants in Selenoprotein Genes and Gender Influence Biomarkers of Se Status in Response to Brazil Nut Supplementation in Healthy Brazilians

Clinical Trial Summary

This study investigates the effect of genetic variations after supplementation with Brazil nuts in healthy Brazilians. Briefly, all the participants will consume one nut a day for 2 months and will stop the intake for more 2 months. Five blood sampling collection will be performed in one month interval, starting at baseline and ending at 2 months without intervention.

Clinical Trial Description

Brazil nuts are the richest source of selenium in nature, a micronutrient that has essential functions in human physiology.

Selenium status can be measured by the quantification of biomarkers in the blood. Previous studies have shown that genetic polymorphisms can affect Se status and modulate risk for chronic diseases. In this study, five biomarkers will be quantified in the blood, before and after supplementation with Brazil nuts. The genetic variants will be used to stratify the biomarkers and multivariate linear regressions will be used to explore the influence of the polymorphisms on concentrations of the biomarkers . ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03111355
Study type Interventional
Source University of Sao Paulo
Contact
Status Completed
Phase N/A
Start date March 1, 2013
Completion date April 19, 2016
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