Diastolic Heart Failure Clinical Trial
Official title:
Effect of Pedometer-Based Walking Intervention on Functional Capacity and Neurohumoral Modulation in Patients With Chronic Heart Failure With Preserved Ejection Fraction: a Multicenter Randomized Controlled Trial
A multicenter randomized controlled trial, with follow-up at 6 and 12 months. Physically
inactive participants with chronic heart failure with preserved or mid-range ejection
fraction will be randomly assigned to intervention or control arms.
The six-month intervention will consist of an individualized pedometer-based walking program
with weekly step goals, monthly face-to-face sessions with the physician, and monthly
telephone calls with the research nurse. The intervention will be based on effective
behavioral principles (goal setting, self-monitoring, personalized feedback).
The primary outcome is the change in 6-minute walk distance at 6 months. Secondary outcomes
include changes in serum biomarkers levels, pulmonary congestion assessed by ultrasound,
average daily step count measured by accelerometry, anthropometric measures, symptoms of
depression, health-related quality of life, self-efficacy, and MAGGIC Risk Score.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT02499601 -
CORolla® TAA for Heart Failure With Preserved Ejection Fraction (HFpEF) and Diastolic Dysfunction (DD)
|
N/A | |
| Completed |
NCT02537041 -
Non-invasive Evaluation of Myocardial Stiffness by Elastography
|
N/A | |
| Completed |
NCT02275793 -
The Regulation of Pulmonary Vascular Resistance in Patients With Heart Failure
|
||
| Withdrawn |
NCT00773084 -
Aliskiren and Renin Inhibition in Diastolic Heart Failure
|
N/A | |
| Terminated |
NCT00293150 -
Reversing Endothelial and Diastolic Dysfunction and Improving Collagen Turnover in Diastolic Heart Failure
|
Phase 4 | |
| Terminated |
NCT01942395 -
Dietary Approaches to Stop Hypertension in 'Diastolic' Heart Failure 2 (DASH-DHF 2)
|
N/A | |
| Recruiting |
NCT03157219 -
Manipal Heart Failure Registry (MHFR)
|
N/A | |
| Terminated |
NCT01778894 -
Mathematical Modeling to Determine Basic Muscle Properties in the Failing Heart
|
||
| Completed |
NCT04154878 -
2 New Measurements Used to Describe the Filling Phase of the Left Ventricle (LV).
|
||
| Recruiting |
NCT01599117 -
A Randomized Trial of Udenafil Therapy in Patients With Heart Failure With Preserved Ejection Fraction [ULTIMATE-HFpEF]
|
Phase 3 | |
| Completed |
NCT01185067 -
Physiological Effects of Grape Seed Extract in Diastolic Heart Failure
|
Phase 1 | |
| Completed |
NCT03338374 -
Cardiac Resynchronisation Therapy Versus Rate-responsive Pacing in Heart Failure With Preserved Ejection Fraction
|
N/A | |
| Completed |
NCT02589977 -
Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF
|
Phase 4 | |
| Completed |
NCT02147613 -
High Intensity Interval Exercise in Diastolic Heart Failure
|
N/A | |
| Terminated |
NCT00083772 -
Use of Nesiritide in the Management of Acute Diastolic Heart Failure
|
Phase 4 | |
| Completed |
NCT00303498 -
A Study of the Effectiveness of Sitaxsentan Sodium in Patients With Diastolic Heart Failure
|
Phase 2 | |
| Terminated |
NCT02254382 -
Positive Airway Pressure Therapy Study in Sleep Apnea and Diastolic Heart Failure
|
N/A | |
| Completed |
NCT00839228 -
Perhexiline Therapy in Heart Failure With Preserved Ejection Fraction Syndrome
|
Phase 2 | |
| Terminated |
NCT00662116 -
Beginning a Randomized Evaluation of the AGE Breaker Alagebrium in Diastolic Heart Failure (BREAK-DHF-I)
|
Phase 2 | |
| Completed |
NCT02916225 -
High Intensity Interval Training Versus Moderate Continuous Training in Heart Failure With Preserved Ejection Fraction
|
N/A |