Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult.

Diarrhea, Secretory Clinical Trial

Official title:

Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03166670
• Other study ID #: PSDCC
• Status: Completed
• Start date: January 1, 2018
• Est. completion date: April 12, 2021

Study information

• Verified date: June 2021
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Diarrhea is one of the most common reasons for people to seek medical advice - but it can range from being a mild, temporary condition, to be life threading condition. It is estimated that there are 2 billion cases of diarrheal disease every year globally, and that 1.9 million children below the age of 5 years, mostly in developing countries, die annually.

Description:

Secretory diarrhea has many causes as infection with bacteria, viruses or protozoa. It results from increased chloride secretion, decreased sodium absorption, or increased mucosal permeability . Parasitic pathogens induce Secretory diarrhea as they infect and damage the absorptive villus tips, leaving Secretory crypts unbalanced, to cause net secretion and diarrhea. Parasitic causes include Cryptosporidium parvum or hominis ,Capillaria philippinensis and Giardia lamblia. Cryptosporidiosis is also recognized as a cause of prolonged and persistent diarrhea in children and persons with impaired immunity. The disease is transmitted via the fecal-oral route from infected hosts. It can be also transmitted following animal contact, ingestion of water (mainly during swimming), or through food. Cryptosporidium has emerged as the most frequently recognized cause of water-associated outbreaks of gastroenteritis. This is because of the oocyst stage in its life cycle; Cryptosporidium can resist disinfection, including chlorination, and can survive for a prolonged period in the environment.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: April 12, 2021
• Est. primary completion date: April 1, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

1. Children presented with secretory diarrhea(acute watery diarrhea) attend to out clinic lab of Assiut University pediatric hospital or admitted in pediatric hospital(gastroenterology department) during the study period.

2. adult patients having acute watery diarrhea attend to out clinic labs of Assiut University hospital or admitted in gastroenterology, nephrology and oncology department of hospital during the study period.

Exclusion Criteria:

1. viral and bacterial causes of diarrhea

2. Patients who were already diagnosed as intestinal inflammatory disease as irritable bowel syndrome.

3. Autoimmune conditions, such as ulcerative colitis, Crohn's disease and coeliac disease.

Related Conditions & MeSH terms

• Chronic Disease
• Diarrhea
• Diarrhea, Secretory

Intervention

Diagnostic Test:
• stool examination
collection of stool specimen and microscopic examination for parasites
• real time polymerase chain reaction
evaluation of genotype of cryptosporidium in stool specimen

Locations

Country	Name	City	State
Egypt	Heba gamal rashed	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

References & Publications (1)

Pawlowski SW, Warren CA, Guerrant R. Diagnosis and treatment of acute or persistent diarrhea. Gastroenterology. 2009 May;136(6):1874-86. doi: 10.1053/j.gastro.2009.02.072. Epub 2009 May 7. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	percentage of patients with positive stool analysis for cryptosporidium	Use of microscopic examination and real time polymerase chain reaction	2 days